Muscarinic receptor agonists and antagonists: Effects on cancer

    Research output: Chapter in Book/Report/Conference proceedingChapter

    60 Scopus citations

    Abstract

    Many epithelial and endothelial cells express a cholinergic autocrine loop in which acetylcholine acts as a growth factor to stimulate cell growth. Cancers derived from these tissues similarly express a cholinergic autocrine loop and ACh secreted by the cancer or neighboring cells interacts with M3 muscarinic receptors expressed on the cancer cells to stimulate tumor growth. Primary proliferative pathways involve MAPK and Akt activation. The ability of muscarinic agonists to stimulate, and M3 antagonists to inhibit tumor growth has clearly been demonstrated for lung and colon cancer. The ability of muscarinic agonists to stimulate growth has been shown for melanoma, pancreatic, breast, ovarian, prostate and brain cancers, suggesting that M3 antagonists will also inhibit growth of these tumors as well. As yet no clinical trials have proven the efficacy of M3 antagonists as cancer therapeutics, though the widespread clinical use and low toxicity of M3 antagonists support the potential role of these drugs as adjuvants to current cancer therapies.

    Original languageEnglish (US)
    Title of host publicationMuscarinic Receptors
    EditorsAllison D. Fryer, Neil M. Nathanson, Arthur Christopoulos
    Pages451-468
    Number of pages18
    DOIs
    StatePublished - Feb 10 2012

    Publication series

    NameHandbook of Experimental Pharmacology
    Volume208
    ISSN (Print)0171-2004
    ISSN (Electronic)1865-0325

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    Keywords

    • Acetylcholine
    • Colon cancer
    • Lung cancer
    • M3 muscarinic receptor
    • Muscarinic receptors
    • Therapy

    ASJC Scopus subject areas

    • Biochemistry
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Spindel, E. R. (2012). Muscarinic receptor agonists and antagonists: Effects on cancer. In A. D. Fryer, N. M. Nathanson, & A. Christopoulos (Eds.), Muscarinic Receptors (pp. 451-468). (Handbook of Experimental Pharmacology; Vol. 208). https://doi.org/10.1007/978-3-642-23274-9_19