Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig

Allison Fryer, J. Maclagan

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

In anaesthetized guinea-pigs, gallamine produced a dose-related potentiation of the bronchoconstriction induced by electrical stimulation of the cervical vagus nerves; (+)-tubocurarine and suxamethonium lacked this effect. The bronchoconstriction produced by intravenous injection of acetylcholine or histamine, however, was not potentiated by gallamine. Vagally-induced bradycardia was abolished by gallamine, confirming antagonism of the effect of acetylcholine on muscarinic receptors in the heart. The muscarinic receptor antagonist pilocarpine, had the opposite effect to gallamine in the lungs as it inhibited vagally-mediated bronchoconstriction. Pretreatment of guinea-pigs with either guanethidine or propranolol did not affect the gallamine-induced potentiation of vagally-mediated bronchoconstriction. The potentiating effect of gallamine in the lung can be explained by blockade of inhibitory, muscarinic receptors located in the parasympathetic nerves supplying the lungs.

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
JournalBritish Journal of Pharmacology
Volume83
Issue number4
StatePublished - 1984
Externally publishedYes

Fingerprint

Gallamine Triethiodide
Muscarinic Receptors
Guinea Pigs
Bronchoconstriction
Lung
Guanethidine
Tubocurarine
Succinylcholine
Pilocarpine
Muscarinic Antagonists
Vagus Nerve
Bradycardia
Propranolol
Intravenous Injections
Histamine
Electric Stimulation
Acetylcholine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig. / Fryer, Allison; Maclagan, J.

In: British Journal of Pharmacology, Vol. 83, No. 4, 1984, p. 973-978.

Research output: Contribution to journalArticle

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