Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

M. H. Kang, K. J. Jeong, W. Y. Kim, H. J. Lee, G. Gong, N. Suh, B. Gyrffy, S. Kim, S. Y. Jeong, Gordon Mills, Y. Y. Park

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. However, the regulatory mechanisms by which MSI2 alters breast cancer pathophysiology have not been clearly identified. Here we demonstrate that MSI2 directly regulates estrogen receptor 1 (ESR1), which is a well-known therapeutic target and has been shown to reflect clinical outcomes in breast cancer. Based on gene expression data analysis, we found that MSI2 expression was highly enriched in estrogen receptor (ER)-positive breast cancer and that MSI2 expression was significantly correlated with ESR1 expression, including expression of ESR1 downstream target genes. In addition, MSI2 levels were associated with clinical outcomes. MSI2 influenced breast cancer cell growth by altering ESR1 function. MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by increasing ESR1 protein stability. Taken together, our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer.

Original languageEnglish (US)
Pages (from-to)1745-1752
Number of pages8
JournalOncogene
Volume36
Issue number12
DOIs
StatePublished - Mar 23 2017
Externally publishedYes

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RNA-Binding Proteins
Estrogen Receptor alpha
Breast Neoplasms
Protein Stability
Estrogen Receptors
Binding Sites
RNA
Gene Expression
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Kang, M. H., Jeong, K. J., Kim, W. Y., Lee, H. J., Gong, G., Suh, N., ... Park, Y. Y. (2017). Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer. Oncogene, 36(12), 1745-1752. https://doi.org/10.1038/onc.2016.327

Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer. / Kang, M. H.; Jeong, K. J.; Kim, W. Y.; Lee, H. J.; Gong, G.; Suh, N.; Gyrffy, B.; Kim, S.; Jeong, S. Y.; Mills, Gordon; Park, Y. Y.

In: Oncogene, Vol. 36, No. 12, 23.03.2017, p. 1745-1752.

Research output: Contribution to journalArticle

Kang, MH, Jeong, KJ, Kim, WY, Lee, HJ, Gong, G, Suh, N, Gyrffy, B, Kim, S, Jeong, SY, Mills, G & Park, YY 2017, 'Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer', Oncogene, vol. 36, no. 12, pp. 1745-1752. https://doi.org/10.1038/onc.2016.327
Kang MH, Jeong KJ, Kim WY, Lee HJ, Gong G, Suh N et al. Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer. Oncogene. 2017 Mar 23;36(12):1745-1752. https://doi.org/10.1038/onc.2016.327
Kang, M. H. ; Jeong, K. J. ; Kim, W. Y. ; Lee, H. J. ; Gong, G. ; Suh, N. ; Gyrffy, B. ; Kim, S. ; Jeong, S. Y. ; Mills, Gordon ; Park, Y. Y. / Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer. In: Oncogene. 2017 ; Vol. 36, No. 12. pp. 1745-1752.
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