Murine monoclonal anti-myelin basic protein (MBP) antibodies inhibit proliferation and cytotoxicity of MBP-specific human T cell clones

Zhang Jingwu, Arthur A. Vandenbark, Marie Paule Jacobs, Halina Offner, Jef C.M. Raus

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Myelin basic protein (MBP)-specific T cell clones, isolated from two patients with multiple sclerosis, expressed the CD4+ phenotype and induced MBP-dependent cytolysis of autologous Epstein-Barr virus (EBV)-transformed B cells. The proliferation and cytolytic activity of the T cell clones were inhibited by four of a panel of five murine monoclonal anti-MBP antibodies in a dose-dependent manner. An isotype-matched antibody with a irrelevant specificity did not have such an effect. These MBP-specific monoclonal antibodies did not block phytohemagglutinin-induced T cell proliferation or allospecific cytotoxicity. These results suggest that some antibodies directed at the autoantigen MBP may play a regulatory role in T cell activation, rather than a pathogenic role, for which there is currently little supporting evidence.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalJournal of Neuroimmunology
Volume24
Issue number1-2
DOIs
StatePublished - Sep 1989

Keywords

  • Monoclonal antibody, myelin basic protein-specific
  • Multiple sclerosis
  • Myelin basic protein
  • T cell clone
  • myelin basic protein-specific

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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