Murine models of substance and alcohol dependence: Unraveling genetic complexities

Kim Cronise, John Jr Crabbe

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Most behavioral traits operate on a phenotypic and genetic continuum, i.e., the phenotypic output is quantitative based on the genetic input. No one gene is either necessary or sufficient to account for the observed phenotype; rather, a collection of genes is responsible. This phenotypic and genetic complexity is particularly evident in psychological disorders. For instance, first-degree relatives of schizophrenics have a 9% risk for a diagnosis, whereas the risk drops to 2% for a third-degree relative (1. These findings suggest that many genes contribute, and as the proportion of shared genes increases among relatives, so does the likelihood of shared diagnosis. Regardless of commonalities among genotypes, phenotypic expression may vary significantly in the frequency and severity of symptoms. This further supports the contention that several genes contribute to the trait, each with small effects.

Original languageEnglish (US)
Title of host publicationComputational Genetics and Genomics: Tools for Understanding Disease
PublisherHumana Press Inc.
Pages177-197
Number of pages21
ISBN (Print)9781592599301, 1592599303, 9781588291875
DOIs
Publication statusPublished - 2005

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ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cronise, K., & Crabbe, J. J. (2005). Murine models of substance and alcohol dependence: Unraveling genetic complexities. In Computational Genetics and Genomics: Tools for Understanding Disease (pp. 177-197). Humana Press Inc.. https://doi.org/10.1007/978-1-59259-930-1_8