Murine model of hepatic breast cancer

Rishi Rikhi, Elizabeth M. Wilson, Olivier Deas, Matthew N. Svalina, John Bial, Atiya Mansoor, Stefano Cairo, Charles Keller

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalBiochemistry and Biophysics Reports
Volume8
DOIs
StatePublished - Dec 1 2016

Fingerprint

Liver Neoplasms
Breast Neoplasms
Liver
Tumors
Screening
Neoplasm Metastasis
Cells
Blood Vessels
Neoplasms
Theoretical Models
Cell Line
Lung
Therapeutics

Keywords

  • Breast cancer
  • Liver metastasis
  • Preclinical model

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Rikhi, R., Wilson, E. M., Deas, O., Svalina, M. N., Bial, J., Mansoor, A., ... Keller, C. (2016). Murine model of hepatic breast cancer. Biochemistry and Biophysics Reports, 8, 1-5. https://doi.org/10.1016/j.bbrep.2016.07.021

Murine model of hepatic breast cancer. / Rikhi, Rishi; Wilson, Elizabeth M.; Deas, Olivier; Svalina, Matthew N.; Bial, John; Mansoor, Atiya; Cairo, Stefano; Keller, Charles.

In: Biochemistry and Biophysics Reports, Vol. 8, 01.12.2016, p. 1-5.

Research output: Contribution to journalArticle

Rikhi, R, Wilson, EM, Deas, O, Svalina, MN, Bial, J, Mansoor, A, Cairo, S & Keller, C 2016, 'Murine model of hepatic breast cancer', Biochemistry and Biophysics Reports, vol. 8, pp. 1-5. https://doi.org/10.1016/j.bbrep.2016.07.021
Rikhi R, Wilson EM, Deas O, Svalina MN, Bial J, Mansoor A et al. Murine model of hepatic breast cancer. Biochemistry and Biophysics Reports. 2016 Dec 1;8:1-5. https://doi.org/10.1016/j.bbrep.2016.07.021
Rikhi, Rishi ; Wilson, Elizabeth M. ; Deas, Olivier ; Svalina, Matthew N. ; Bial, John ; Mansoor, Atiya ; Cairo, Stefano ; Keller, Charles. / Murine model of hepatic breast cancer. In: Biochemistry and Biophysics Reports. 2016 ; Vol. 8. pp. 1-5.
@article{4b952a02b95d4a44addbb330ce445cd5,
title = "Murine model of hepatic breast cancer",
abstract = "Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.",
keywords = "Breast cancer, Liver metastasis, Preclinical model",
author = "Rishi Rikhi and Wilson, {Elizabeth M.} and Olivier Deas and Svalina, {Matthew N.} and John Bial and Atiya Mansoor and Stefano Cairo and Charles Keller",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.bbrep.2016.07.021",
language = "English (US)",
volume = "8",
pages = "1--5",
journal = "Biochemistry and Biophysics Reports",
issn = "2405-5808",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Murine model of hepatic breast cancer

AU - Rikhi, Rishi

AU - Wilson, Elizabeth M.

AU - Deas, Olivier

AU - Svalina, Matthew N.

AU - Bial, John

AU - Mansoor, Atiya

AU - Cairo, Stefano

AU - Keller, Charles

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.

AB - Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.

KW - Breast cancer

KW - Liver metastasis

KW - Preclinical model

UR - http://www.scopus.com/inward/record.url?scp=84982144532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982144532&partnerID=8YFLogxK

U2 - 10.1016/j.bbrep.2016.07.021

DO - 10.1016/j.bbrep.2016.07.021

M3 - Article

AN - SCOPUS:84982144532

VL - 8

SP - 1

EP - 5

JO - Biochemistry and Biophysics Reports

JF - Biochemistry and Biophysics Reports

SN - 2405-5808

ER -