Murine model of hepatic breast cancer

Rishi Rikhi, Elizabeth M. Wilson, Olivier Deas, Matthew N. Svalina, John Bial, Atiya Mansoor, Stefano Cairo, Charles Keller

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalBiochemistry and Biophysics Reports
Volume8
DOIs
StatePublished - Dec 1 2016

Keywords

  • Breast cancer
  • Liver metastasis
  • Preclinical model

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Murine model of hepatic breast cancer'. Together they form a unique fingerprint.

  • Cite this

    Rikhi, R., Wilson, E. M., Deas, O., Svalina, M. N., Bial, J., Mansoor, A., Cairo, S., & Keller, C. (2016). Murine model of hepatic breast cancer. Biochemistry and Biophysics Reports, 8, 1-5. https://doi.org/10.1016/j.bbrep.2016.07.021