Murine model of hepatic breast cancer

Rishi Rikhi; Elizabeth M. Wilson; Olivier Deas; Matthew N. Svalina; John Bial; Atiya Mansoor; Stefano Cairo; Charles Keller

doi:10.1016/j.bbrep.2016.07.021

Murine model of hepatic breast cancer

Rishi Rikhi, Elizabeth M. Wilson, Olivier Deas, Matthew N. Svalina, John Bial, Atiya Mansoor, Stefano Cairo, Charles Keller

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Biochemistry and Biophysics Reports
Volume	8
DOIs	https://doi.org/10.1016/j.bbrep.2016.07.021
State	Published - Dec 1 2016

Keywords

Breast cancer
Liver metastasis
Preclinical model

ASJC Scopus subject areas

Biophysics
Biochemistry

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10.1016/j.bbrep.2016.07.021

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title = "Murine model of hepatic breast cancer",

abstract = "Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.",

keywords = "Breast cancer, Liver metastasis, Preclinical model",

author = "Rishi Rikhi and Wilson, {Elizabeth M.} and Olivier Deas and Svalina, {Matthew N.} and John Bial and Atiya Mansoor and Stefano Cairo and Charles Keller",

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doi = "10.1016/j.bbrep.2016.07.021",

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T1 - Murine model of hepatic breast cancer

AU - Rikhi, Rishi

AU - Wilson, Elizabeth M.

AU - Deas, Olivier

AU - Svalina, Matthew N.

AU - Bial, John

AU - Mansoor, Atiya

AU - Cairo, Stefano

AU - Keller, Charles

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.

AB - Background and aims Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths in this population. Breast cancer related deaths have declined due to screening and adjuvant therapies, yet a driving clinical need exists to better understand the cause of the deadliest aspect of breast cancer, metastatic disease. Breast cancer metastasizes to several distant organs, the liver being the third most common site. To date, very few murine models of hepatic breast cancer exist. Methods In this study, a novel murine model of liver breast cancer using the MDA-MB-231 cell line is introduced as an experimental (preclinical) model. Results Histological typing revealed consistent hepatic breast cancer tumor foci. Common features of the murine model were vascular invasion, lung metastasis and peritoneal seeding. Conclusions The novel murine model of hepatic breast cancer established in this study provides a tool to be used to investigate mechanisms of hepatic metastasis and to test potential therapeutic interventions.

KW - Breast cancer

KW - Liver metastasis

KW - Preclinical model

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Murine model of hepatic breast cancer

Abstract

Keywords

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