Murine cytomegalovirus interference with antigen presentation contributes to the inability of CD8 T cells to control virus in the salivary gland

Xiuju Lu, Amelia K. Pinto, Ann M. Kelly, Kathy S. Cho, Ann B. Hill

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMV's known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells' inability to control virus in the salivary gland.

Original languageEnglish (US)
Pages (from-to)4200-4202
Number of pages3
JournalJournal of virology
Volume80
Issue number8
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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