mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development

Kristina Schimmelpfeng, Mareike Strunk, Wilm Tobias Stork, Christian Klämbt

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Throughout development cell-cell interactions are of pivotal importance. Cells bind to each other or share information via secreted signaling molecules. To a large degree, these processes are modulated by post-translational modifications of membrane proteins. Glycan-chains are frequently added to membrane proteins and assist their exact function at the cell surface. In addition, the glycosylation pathway is required to generate GPI-linkage in the endoplasmatic reticulum. Here, we describe the analysis of the cabrio/mummy gene, which encodes an UDP-N-acetylglucosamine diphosphorylase. This is a well-conserved and central enzyme in the glycosylation pathway. As expected from this central role in glycosylation, cabrio/mummy mutants show many phenotypic traits ranging from CNS fasciculation defects to defects in dorsal closure and eye development. These phenotypes correlate well with specific glycosylation and GPI-anchorage defects in mummy mutants.

Original languageEnglish (US)
Pages (from-to)487-499
Number of pages13
JournalMechanisms of Development
Volume123
Issue number6
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

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Keywords

  • Axon patterning
  • Dorsal closure
  • Drosophila
  • UDP-N-acetylglucosamine-diphosphorylase

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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