Multivariate risks among extremely premature infants.

M. E. Msall, G. M. Buck, Brian Rogers, D. P. Merke, C. C. Wan, N. L. Catanzaro, W. A. Zorn

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

This study was designed to identify risk factors for mortality and morbidity of extremely premature infants born in the surfactant era. The study cohort included 194 infants born at <29 weeks' gestation at one regional tertiary center between 1983 and 1986. Forty-one infants died. Blinded neurodevelopmental assessments were performed on 149 of 153 (97%) survivors at a mean age of 52 months. Thirty-one (21%) survivors had major impairments: 15 had mental retardation, 8 had multiple impairments, 7 had cerebral palsy, and 1 was blind. Logistic regression analysis identifies five significant risk factors for mortality: grade III or IV intraventricular hemorrhage, birth weight <800 gm, 5-minute Apgar score <or = 3, male sex, and absence of surfactant therapy. Significant risk factors for any major impairment included sepsis (relative risks [RR] = 6.4), male sex (RR = 3.1), and nonwhite race (RR = 2.8). Hydrocephalus requiring shunting was a significant risk factor for cerebral palsy (RR = 16.4) and neonatal retardation (RR = 16.0). Nonwhite race (RR = 7.3), sepsis (RR = 6.8), and male sex (RR = 3.7) also were significant risk factors for mental retardation. Confirmation of these risk factors should facilitate development of targeted interventions for optimizing long-term outcome.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalJournal of perinatology : official journal of the California Perinatal Association
Volume14
Issue number1
StatePublished - Jan 1994
Externally publishedYes

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Extremely Premature Infants
Cerebral Palsy
Surface-Active Agents
Intellectual Disability
Survivors
Sepsis
Apgar Score
Mortality
Hydrocephalus
Birth Weight
Cohort Studies
Logistic Models
Regression Analysis
Hemorrhage
Morbidity
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Msall, M. E., Buck, G. M., Rogers, B., Merke, D. P., Wan, C. C., Catanzaro, N. L., & Zorn, W. A. (1994). Multivariate risks among extremely premature infants. Journal of perinatology : official journal of the California Perinatal Association, 14(1), 41-47.

Multivariate risks among extremely premature infants. / Msall, M. E.; Buck, G. M.; Rogers, Brian; Merke, D. P.; Wan, C. C.; Catanzaro, N. L.; Zorn, W. A.

In: Journal of perinatology : official journal of the California Perinatal Association, Vol. 14, No. 1, 01.1994, p. 41-47.

Research output: Contribution to journalArticle

Msall, ME, Buck, GM, Rogers, B, Merke, DP, Wan, CC, Catanzaro, NL & Zorn, WA 1994, 'Multivariate risks among extremely premature infants.', Journal of perinatology : official journal of the California Perinatal Association, vol. 14, no. 1, pp. 41-47.
Msall, M. E. ; Buck, G. M. ; Rogers, Brian ; Merke, D. P. ; Wan, C. C. ; Catanzaro, N. L. ; Zorn, W. A. / Multivariate risks among extremely premature infants. In: Journal of perinatology : official journal of the California Perinatal Association. 1994 ; Vol. 14, No. 1. pp. 41-47.
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