Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America

James R. Nethercott; D. Linn Holness; Robert M. Adams; Donald V. Belsito; Vincent A. DeLeo; Edward A. Emmett; Joseph F. Fowler; Alexander M. Fisher; Walter G. Larsen; Howard I. Maibach; James G. Marks; Robert L. Reitschel; Lawrence Rosenthal; William Schorr; Francis J. Storrs; James S. Taylor

doi:10.1097/01634989-199403000-00002

Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America

James R. Nethercott, D. Linn Holness, Robert M. Adams, Donald V. Belsito, Vincent A. DeLeo, Edward A. Emmett, Joseph F. Fowler, Alexander M. Fisher, Walter G. Larsen, Howard I. Maibach, James G. Marks, Robert L. Reitschel, Lawrence Rosenthal, William Schorr, Francis J. Storrs, James S. Taylor

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31 Scopus citations

Abstract

Standardized patch tests were performed on 3,974 patients between August 1, 1985 and July 31, 1989. Significant determinants of positive responses based on previously reported bivariate analysis of response were entered into a logistic regression model; the contribution of each factor to response to each of 27 test substances with which the patients were tested was evaluated. For 14 test substances, age increased the odds of response; nickel was striking in that increasing age decreased the odds of a positive response. Specific contactants were found to be associated with gender and topographical location of the eczematous dermatitis leading to the application of the patch tests. Atopic dermatitis was associated with a lower odds of response to P-phenylenediamine, but in no instance was associated with increased odds of a positive response.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	American Journal of Contact Dermatitis
Volume	5
Issue number	1
DOIs	https://doi.org/10.1097/01634989-199403000-00002
State	Published - Mar 1994
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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10.1097/01634989-199403000-00002

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Nethercott, J. R., Linn Holness, D., Adams, R. M., Belsito, D. V., DeLeo, V. A., Emmett, E. A., Fowler, J. F., Fisher, A. M., Larsen, W. G., Maibach, H. I., Marks, J. G., Reitschel, R. L., Rosenthal, L., Schorr, W., Storrs, F. J., & Taylor, J. S. (1994). Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America. American Journal of Contact Dermatitis, 5(1), 13-18. https://doi.org/10.1097/01634989-199403000-00002

Nethercott, JR, Linn Holness, D, Adams, RM, Belsito, DV, DeLeo, VA, Emmett, EA, Fowler, JF, Fisher, AM, Larsen, WG, Maibach, HI, Marks, JG, Reitschel, RL, Rosenthal, L, Schorr, W, Storrs, FJ & Taylor, JS 1994, 'Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America', American Journal of Contact Dermatitis, vol. 5, no. 1, pp. 13-18. https://doi.org/10.1097/01634989-199403000-00002

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title = "Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America",

abstract = "Standardized patch tests were performed on 3,974 patients between August 1, 1985 and July 31, 1989. Significant determinants of positive responses based on previously reported bivariate analysis of response were entered into a logistic regression model; the contribution of each factor to response to each of 27 test substances with which the patients were tested was evaluated. For 14 test substances, age increased the odds of response; nickel was striking in that increasing age decreased the odds of a positive response. Specific contactants were found to be associated with gender and topographical location of the eczematous dermatitis leading to the application of the patch tests. Atopic dermatitis was associated with a lower odds of response to P-phenylenediamine, but in no instance was associated with increased odds of a positive response.",

author = "Nethercott, {James R.} and {Linn Holness}, D. and Adams, {Robert M.} and Belsito, {Donald V.} and DeLeo, {Vincent A.} and Emmett, {Edward A.} and Fowler, {Joseph F.} and Fisher, {Alexander M.} and Larsen, {Walter G.} and Maibach, {Howard I.} and Marks, {James G.} and Reitschel, {Robert L.} and Lawrence Rosenthal and William Schorr and Storrs, {Francis J.} and Taylor, {James S.}",

year = "1994",

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doi = "10.1097/01634989-199403000-00002",

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AU - DeLeo, Vincent A.

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AU - Larsen, Walter G.

AU - Maibach, Howard I.

AU - Marks, James G.

AU - Reitschel, Robert L.

AU - Rosenthal, Lawrence

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Multivariate analysis of the effect of selected factors on the elicitation of patch test response to 28 common environmental contactants in North America

Abstract

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