Multivariate Analysis of Left Ventricular Mass Determinants in Adults

Different Patterns in Men and Women

Richard S. Meltzer, Diana Rinkevich, Shimon A. Reisner, Michael Motro, Bruno Becker, Zvi Vered

Research output: Contribution to journalArticle

Abstract

Echocardiographic left ventricular mass (LVM) estimates are strong predictors of subsequent mortality and cardiovascular events. It is known that blood pressure (BP), weight (WT), and age are significantly correlated with LVM. We hypothesized that stroke volume (SV) measured by Doppler echocardiography would also be correlated with LVM. Two hundred and thirteen patients referred for routine echocardiography had determination of LVM, cuff BP, and Doppler SV. Those with localized LV disease, valvular disease, or cor pulmonale were excluded. In both men and women, systolic BP (SBP) was more closely correlated with LVM than was diastolic blood pressure or mean arterial pressure, and SV was more closely correlated with LVM than cardiac output or cardiac index. Stepwise regression, followed by multiple regression showed that four variables (WT, SV, SBP, and AGE) explained 32.3% of the variability in LVM in men and 48.5% of the variability in LVM in women. WT and SV were significant determinants of LVM in both men and women. Age was also significant in men and SBP was also significant in women. For both men and women, SV was more significantly correlated with LVM than was SBP. The changes in LVM associated with 1 SD increments of SV and SBP, respectively, were 8 and 5 g for men and 13 and 11 g for women. We conclude that men and women have different patterns of variables influencing LVM. Doppler echocardiographic SV is a newly described determinant of LVM that has a greater correlation with LVM than does SBP. This study reemphasizes the importance of WT as the major determinant of LVM.

Original languageEnglish (US)
Pages (from-to)35-43
Number of pages9
JournalEchocardiography
Volume13
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Stroke Volume
Multivariate Analysis
Blood Pressure
Weights and Measures
Pulmonary Heart Disease
Doppler Echocardiography
Cardiac Output
Echocardiography
Arterial Pressure
Mortality

Keywords

  • Echocardiography
  • Left ventricular hypertrophy
  • Left ventricular mass
  • Stroke volume

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Meltzer, R. S., Rinkevich, D., Reisner, S. A., Motro, M., Becker, B., & Vered, Z. (1996). Multivariate Analysis of Left Ventricular Mass Determinants in Adults: Different Patterns in Men and Women. Echocardiography, 13(1), 35-43.

Multivariate Analysis of Left Ventricular Mass Determinants in Adults : Different Patterns in Men and Women. / Meltzer, Richard S.; Rinkevich, Diana; Reisner, Shimon A.; Motro, Michael; Becker, Bruno; Vered, Zvi.

In: Echocardiography, Vol. 13, No. 1, 1996, p. 35-43.

Research output: Contribution to journalArticle

Meltzer, RS, Rinkevich, D, Reisner, SA, Motro, M, Becker, B & Vered, Z 1996, 'Multivariate Analysis of Left Ventricular Mass Determinants in Adults: Different Patterns in Men and Women', Echocardiography, vol. 13, no. 1, pp. 35-43.
Meltzer, Richard S. ; Rinkevich, Diana ; Reisner, Shimon A. ; Motro, Michael ; Becker, Bruno ; Vered, Zvi. / Multivariate Analysis of Left Ventricular Mass Determinants in Adults : Different Patterns in Men and Women. In: Echocardiography. 1996 ; Vol. 13, No. 1. pp. 35-43.
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