Multiple sclerosis

Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy

Gary Nesbit, Glenn S. Forbes, Bernd W. Scheithauer, Haruo Okazaki, Moses Rodriguez

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

The authors retrospectively reviewed the cases of 40 patients with biopsyor autopsy-proved inflammatory demyelination consistent with multiple sclerosis (MS); each patient underwent magnetic resonance (MR) and/or computed tomographic (CT) imaging. In review of the 32 MR and 30 CT examinations, three predominant radiologic patterns were apparent: (a) relatively small homogeneous lesions with no or minimal diffuse enhancement; (b) hypoattenuating lesions on CT scans and hypointense lesions on short-TR MR images, with a contrast material-enhanced, isoattenuating or isointense ring; and (c) lesions that were more infiltrative and ill defined, with mixed attenuation and signal intensity and scattered enhancement. A common radiologic feature was lack of mass effect or edema in white matter surrounding even large lesions. In all but four patients the lesions were classified as active by using both histologic and clinical criteria. Histologically active lesions had various radiologic appearances; however, in all contrast-enhanced studies they demonstrated some form of enhancement. Inactive lesions were homogeneously hypoattenuating on CT scans, hypointense on short-TR MR images, and hyper-intense on unenhanced, long-TR MR images.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalRadiology
Volume180
Issue number2
StatePublished - Aug 1991
Externally publishedYes

Fingerprint

Multiple Sclerosis
Autopsy
Magnetic Resonance Spectroscopy
Biopsy
Demyelinating Diseases
Contrast Media
Edema

Keywords

  • Brain, CT, 10.1211
  • Brain, MR studies, 10.1214
  • Gadolinium, 10.1211, 10.1214
  • Sclerosis, multiple, 10.871

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Nesbit, G., Forbes, G. S., Scheithauer, B. W., Okazaki, H., & Rodriguez, M. (1991). Multiple sclerosis: Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology, 180(2), 467-474.

Multiple sclerosis : Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. / Nesbit, Gary; Forbes, Glenn S.; Scheithauer, Bernd W.; Okazaki, Haruo; Rodriguez, Moses.

In: Radiology, Vol. 180, No. 2, 08.1991, p. 467-474.

Research output: Contribution to journalArticle

Nesbit, G, Forbes, GS, Scheithauer, BW, Okazaki, H & Rodriguez, M 1991, 'Multiple sclerosis: Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy', Radiology, vol. 180, no. 2, pp. 467-474.
Nesbit G, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M. Multiple sclerosis: Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology. 1991 Aug;180(2):467-474.
Nesbit, Gary ; Forbes, Glenn S. ; Scheithauer, Bernd W. ; Okazaki, Haruo ; Rodriguez, Moses. / Multiple sclerosis : Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. In: Radiology. 1991 ; Vol. 180, No. 2. pp. 467-474.
@article{8061dc8719ce4254bd0f488c179a4d92,
title = "Multiple sclerosis: Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy",
abstract = "The authors retrospectively reviewed the cases of 40 patients with biopsyor autopsy-proved inflammatory demyelination consistent with multiple sclerosis (MS); each patient underwent magnetic resonance (MR) and/or computed tomographic (CT) imaging. In review of the 32 MR and 30 CT examinations, three predominant radiologic patterns were apparent: (a) relatively small homogeneous lesions with no or minimal diffuse enhancement; (b) hypoattenuating lesions on CT scans and hypointense lesions on short-TR MR images, with a contrast material-enhanced, isoattenuating or isointense ring; and (c) lesions that were more infiltrative and ill defined, with mixed attenuation and signal intensity and scattered enhancement. A common radiologic feature was lack of mass effect or edema in white matter surrounding even large lesions. In all but four patients the lesions were classified as active by using both histologic and clinical criteria. Histologically active lesions had various radiologic appearances; however, in all contrast-enhanced studies they demonstrated some form of enhancement. Inactive lesions were homogeneously hypoattenuating on CT scans, hypointense on short-TR MR images, and hyper-intense on unenhanced, long-TR MR images.",
keywords = "Brain, CT, 10.1211, Brain, MR studies, 10.1214, Gadolinium, 10.1211, 10.1214, Sclerosis, multiple, 10.871",
author = "Gary Nesbit and Forbes, {Glenn S.} and Scheithauer, {Bernd W.} and Haruo Okazaki and Moses Rodriguez",
year = "1991",
month = "8",
language = "English (US)",
volume = "180",
pages = "467--474",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Multiple sclerosis

T2 - Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy

AU - Nesbit, Gary

AU - Forbes, Glenn S.

AU - Scheithauer, Bernd W.

AU - Okazaki, Haruo

AU - Rodriguez, Moses

PY - 1991/8

Y1 - 1991/8

N2 - The authors retrospectively reviewed the cases of 40 patients with biopsyor autopsy-proved inflammatory demyelination consistent with multiple sclerosis (MS); each patient underwent magnetic resonance (MR) and/or computed tomographic (CT) imaging. In review of the 32 MR and 30 CT examinations, three predominant radiologic patterns were apparent: (a) relatively small homogeneous lesions with no or minimal diffuse enhancement; (b) hypoattenuating lesions on CT scans and hypointense lesions on short-TR MR images, with a contrast material-enhanced, isoattenuating or isointense ring; and (c) lesions that were more infiltrative and ill defined, with mixed attenuation and signal intensity and scattered enhancement. A common radiologic feature was lack of mass effect or edema in white matter surrounding even large lesions. In all but four patients the lesions were classified as active by using both histologic and clinical criteria. Histologically active lesions had various radiologic appearances; however, in all contrast-enhanced studies they demonstrated some form of enhancement. Inactive lesions were homogeneously hypoattenuating on CT scans, hypointense on short-TR MR images, and hyper-intense on unenhanced, long-TR MR images.

AB - The authors retrospectively reviewed the cases of 40 patients with biopsyor autopsy-proved inflammatory demyelination consistent with multiple sclerosis (MS); each patient underwent magnetic resonance (MR) and/or computed tomographic (CT) imaging. In review of the 32 MR and 30 CT examinations, three predominant radiologic patterns were apparent: (a) relatively small homogeneous lesions with no or minimal diffuse enhancement; (b) hypoattenuating lesions on CT scans and hypointense lesions on short-TR MR images, with a contrast material-enhanced, isoattenuating or isointense ring; and (c) lesions that were more infiltrative and ill defined, with mixed attenuation and signal intensity and scattered enhancement. A common radiologic feature was lack of mass effect or edema in white matter surrounding even large lesions. In all but four patients the lesions were classified as active by using both histologic and clinical criteria. Histologically active lesions had various radiologic appearances; however, in all contrast-enhanced studies they demonstrated some form of enhancement. Inactive lesions were homogeneously hypoattenuating on CT scans, hypointense on short-TR MR images, and hyper-intense on unenhanced, long-TR MR images.

KW - Brain, CT, 10.1211

KW - Brain, MR studies, 10.1214

KW - Gadolinium, 10.1211, 10.1214

KW - Sclerosis, multiple, 10.871

UR - http://www.scopus.com/inward/record.url?scp=0025871038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025871038&partnerID=8YFLogxK

M3 - Article

VL - 180

SP - 467

EP - 474

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -