Multiple pathways transmit neuroprotective effects of gonadal steroids

Damani N. Bryant, Laird C. Sheldahl, Lisa K. Marriott, Robert A. Shapiro, Daniel M. Dorsa

Research output: Contribution to journalReview article

87 Scopus citations


Numerous preclinical studies suggest that gonadal steroids, particularly estrogen, may be neuroprotective against insult or disease progression. This paper reviews the mechanisms contributing to estrogen-mediated neuroprotection. Rapid signaling pathways, such as MAPK, PI3K, Akt, and PKC, are required for estrogen's ability to provide neuroprotection. These rapid signaling pathways converge on genomic pathways to modulate transcription of E2-responsive genes via ERE-dependent and ERE-independent mechanisms. It is clear that both rapid signaling and transcription are important for estrogen's neuroprotective effects. A mechanistic understanding of estrogen-mediated neuroprotection is crucial for the development of therapeutic interventions that enhance quality of life without deleterious side effects.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
Issue number2
StatePublished - Jul 27 2006


  • In vitro model
  • Neuroprotection
  • Transcription

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Bryant, D. N., Sheldahl, L. C., Marriott, L. K., Shapiro, R. A., & Dorsa, D. M. (2006). Multiple pathways transmit neuroprotective effects of gonadal steroids. Endocrine, 29(2), 199-207.