Multiple mechanisms underlie burst firing in rat midbrain dopamine neurons in vitro

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularly in slices of rat midbrain. However, apamin-induced bursting required injection of depolarizing currents, and was mimicked by Bay K8644 and blocked by nifedipine. In contrast, NMDA-induced bursting required hyperpolarizing currents and was not blocked by nifedipine. Our results show that burst firing can be evoked in dopamine neurons via two different mechanisms.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalBrain research
Volume1019
Issue number1-2
DOIs
StatePublished - Sep 3 2004

Keywords

  • Apamin
  • Excitable membranes and synaptic transmission
  • N-Methyl-D-aspartate
  • Nifedipine
  • Postsynaptic mechanisms
  • Substantia nigra
  • Ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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