Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1

Dennis Koop, Daniel J. Tierney

Research output: Contribution to journalArticle

215 Citations (Scopus)

Abstract

Cytochrome P450IIE1 is involved in the metabolic activation of many xenobiotics involved with human toxicity. In particular, cellular concentrations of P450IIE1 are significantly induced by the most widely abused drug in our society today, alcohol. As a result, the synthesis and degradation of this form of P450 has significant health consequences. The regulation of the steady-state concentration of P450IIE1 is an extremely complex process. The enzyme is regulated by transcriptional activation, mRNA stabilization, increased mRNA translatability and decreased protein degradation. The principal mechanism which controls the induction process depends on the chemical nature of the inducer, the age, and the nutritional and hormonal status of the animal. There also appear to be significant sex differences in the expression of P450IIE1. It is entirely possible that the regulation of the enzyme concentration under any given set of conditions will involve all of the mechanisms to different extents.

Original languageEnglish (US)
Pages (from-to)429-435
Number of pages7
JournalBioEssays
Volume12
Issue number9
StatePublished - 1990
Externally publishedYes

Fingerprint

Cytochromes
cytochromes
Ethanol
Chemical activation
ethanol
Degradation
Messenger RNA
Xenobiotics
transcriptional activation
Enzymes
xenobiotics
enzymes
protein degradation
Nutritional Status
gender differences
Sex Characteristics
Transcriptional Activation
Proteolysis
Toxicity
Animals

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Neuroscience (miscellaneous)

Cite this

Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1. / Koop, Dennis; Tierney, Daniel J.

In: BioEssays, Vol. 12, No. 9, 1990, p. 429-435.

Research output: Contribution to journalArticle

Koop, Dennis ; Tierney, Daniel J. / Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450IIE1. In: BioEssays. 1990 ; Vol. 12, No. 9. pp. 429-435.
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