Multiple faces of BDNF in cocaine addiction

Xuan Li, Marina Wolf

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) has been found to play roles in many types of plasticity including drug addiction. Here, we focus on rodent studies over the past two decades that have demonstrated diverse roles of BDNF in models of cocaine addiction. First, we will provide an overview of studies showing that cocaine exposure alters (and generally increases) BDNF levels in reward-related regions including the ventral tegmental area, nucleus accumbens, prefrontal cortex, and amygdala. Then we will review evidence that BDNF contributes to behavioral changes in animal models of cocaine addiction, focusing on conditioned place preference, behavioral sensitization, maintenance and reinstatement of self-administration, and incubation of cocaine craving. Last, we will review the role of BDNF in synaptic plasticity, particularly as it relates to plasticity of AMPA receptor transmission after cocaine exposure. We conclude that BDNF regulates cocaine-induced behaviors in a highly complex manner that varies depending on the brain region (and even among different cell types within the same brain region), the nature of cocaine exposure, and the "addiction phase" examined (e.g., acquisition vs maintenance; early vs late withdrawal). These complexities make BDNF a daunting therapeutic target for treating cocaine addiction. However, recent clinical evidence suggests that the serum BDNF level may serve as a biomarker in cocaine addicts to predict future relapse, providing an alternative direction for exploring BDNF's potential relevance to treating cocaine addiction.

Original languageEnglish (US)
Pages (from-to)240-254
Number of pages15
JournalBehavioural Brain Research
Volume279
DOIs
StatePublished - Feb 5 2015
Externally publishedYes

Fingerprint

Cocaine-Related Disorders
Brain-Derived Neurotrophic Factor
Cocaine
Tegmentum Mesencephali
Maintenance
Ventral Tegmental Area
Neuronal Plasticity
Self Administration
AMPA Receptors
Nucleus Accumbens
Brain
Amygdala
Prefrontal Cortex
Reward
Substance-Related Disorders
Rodentia
Animal Models
Biomarkers
Recurrence

Keywords

  • AMPA receptor
  • BDNF
  • Cocaine addiction
  • TrkB

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Multiple faces of BDNF in cocaine addiction. / Li, Xuan; Wolf, Marina.

In: Behavioural Brain Research, Vol. 279, 05.02.2015, p. 240-254.

Research output: Contribution to journalReview article

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