Multiple exostosis: A short study of abnormalities near the growth plate

Atiya Mansoor, Rodney K. Beals

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The pathogenesis of multiple exostosis has been controversial with many theories put forward including the structural/mechanical theory, which emphasizes that the osteochondroma arises in the displaced growth plate cartilage penetrating a defective periosteum. Recently, molecular genetics has offered the neoplastic model with tumor suppressor genes implicated in the development and pathogenesis of exostosis. In this study, we demonstrated the spectrum of histological abnormalities in the developing exostosis present on the surface of the bone at the physis. Seven skeletally immature patients with multiple exostoses were used in this study. The patients' families were advised of and consented to the proposed study. Coincident with removal of symptomatic exostoses that was adjacent to the physis, a thin strip of bone with overlying periosteum was removed to include the edge of the physis. This was followed by formalin fixation and routine paraffin embedding. We demonstrated the earliest lesion as a microchondroma within the periosteum adjacent to the normal physis (also called the 'groove of Ranvier'). More mature progressively larger lesions showing enchondral ossification were seen distally. The periosteum and the perichondrium were intact with normal physis. Our observations give support to the fact that precursor cells in the periosteum adjacent to the physis (also called the 'groove of Ranvier') gives rise to the chondrocytes that clonally expands and develops into exostosis.

Original languageEnglish (US)
Pages (from-to)363-365
Number of pages3
JournalJournal of Pediatric Orthopaedics Part B
Volume16
Issue number5
DOIs
StatePublished - Sep 2007

Fingerprint

Multiple Hereditary Exostoses
Periosteum
Growth Plate
Exostoses
Paraffin Embedding
Osteochondroma
Bone and Bones
Chondrocytes
Tumor Suppressor Genes
Osteogenesis
Formaldehyde
Cartilage
Molecular Biology

Keywords

  • Exostosis
  • Hereditary exostosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Multiple exostosis : A short study of abnormalities near the growth plate. / Mansoor, Atiya; Beals, Rodney K.

In: Journal of Pediatric Orthopaedics Part B, Vol. 16, No. 5, 09.2007, p. 363-365.

Research output: Contribution to journalArticle

Mansoor, Atiya ; Beals, Rodney K. / Multiple exostosis : A short study of abnormalities near the growth plate. In: Journal of Pediatric Orthopaedics Part B. 2007 ; Vol. 16, No. 5. pp. 363-365.
@article{dd7dc6a550da473ba1a021df7fb220c4,
title = "Multiple exostosis: A short study of abnormalities near the growth plate",
abstract = "The pathogenesis of multiple exostosis has been controversial with many theories put forward including the structural/mechanical theory, which emphasizes that the osteochondroma arises in the displaced growth plate cartilage penetrating a defective periosteum. Recently, molecular genetics has offered the neoplastic model with tumor suppressor genes implicated in the development and pathogenesis of exostosis. In this study, we demonstrated the spectrum of histological abnormalities in the developing exostosis present on the surface of the bone at the physis. Seven skeletally immature patients with multiple exostoses were used in this study. The patients' families were advised of and consented to the proposed study. Coincident with removal of symptomatic exostoses that was adjacent to the physis, a thin strip of bone with overlying periosteum was removed to include the edge of the physis. This was followed by formalin fixation and routine paraffin embedding. We demonstrated the earliest lesion as a microchondroma within the periosteum adjacent to the normal physis (also called the 'groove of Ranvier'). More mature progressively larger lesions showing enchondral ossification were seen distally. The periosteum and the perichondrium were intact with normal physis. Our observations give support to the fact that precursor cells in the periosteum adjacent to the physis (also called the 'groove of Ranvier') gives rise to the chondrocytes that clonally expands and develops into exostosis.",
keywords = "Exostosis, Hereditary exostosis",
author = "Atiya Mansoor and Beals, {Rodney K.}",
year = "2007",
month = "9",
doi = "10.1097/BPB.0b013e32823ed01a",
language = "English (US)",
volume = "16",
pages = "363--365",
journal = "Journal of Pediatric Orthopaedics Part B",
issn = "1060-152X",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Multiple exostosis

T2 - A short study of abnormalities near the growth plate

AU - Mansoor, Atiya

AU - Beals, Rodney K.

PY - 2007/9

Y1 - 2007/9

N2 - The pathogenesis of multiple exostosis has been controversial with many theories put forward including the structural/mechanical theory, which emphasizes that the osteochondroma arises in the displaced growth plate cartilage penetrating a defective periosteum. Recently, molecular genetics has offered the neoplastic model with tumor suppressor genes implicated in the development and pathogenesis of exostosis. In this study, we demonstrated the spectrum of histological abnormalities in the developing exostosis present on the surface of the bone at the physis. Seven skeletally immature patients with multiple exostoses were used in this study. The patients' families were advised of and consented to the proposed study. Coincident with removal of symptomatic exostoses that was adjacent to the physis, a thin strip of bone with overlying periosteum was removed to include the edge of the physis. This was followed by formalin fixation and routine paraffin embedding. We demonstrated the earliest lesion as a microchondroma within the periosteum adjacent to the normal physis (also called the 'groove of Ranvier'). More mature progressively larger lesions showing enchondral ossification were seen distally. The periosteum and the perichondrium were intact with normal physis. Our observations give support to the fact that precursor cells in the periosteum adjacent to the physis (also called the 'groove of Ranvier') gives rise to the chondrocytes that clonally expands and develops into exostosis.

AB - The pathogenesis of multiple exostosis has been controversial with many theories put forward including the structural/mechanical theory, which emphasizes that the osteochondroma arises in the displaced growth plate cartilage penetrating a defective periosteum. Recently, molecular genetics has offered the neoplastic model with tumor suppressor genes implicated in the development and pathogenesis of exostosis. In this study, we demonstrated the spectrum of histological abnormalities in the developing exostosis present on the surface of the bone at the physis. Seven skeletally immature patients with multiple exostoses were used in this study. The patients' families were advised of and consented to the proposed study. Coincident with removal of symptomatic exostoses that was adjacent to the physis, a thin strip of bone with overlying periosteum was removed to include the edge of the physis. This was followed by formalin fixation and routine paraffin embedding. We demonstrated the earliest lesion as a microchondroma within the periosteum adjacent to the normal physis (also called the 'groove of Ranvier'). More mature progressively larger lesions showing enchondral ossification were seen distally. The periosteum and the perichondrium were intact with normal physis. Our observations give support to the fact that precursor cells in the periosteum adjacent to the physis (also called the 'groove of Ranvier') gives rise to the chondrocytes that clonally expands and develops into exostosis.

KW - Exostosis

KW - Hereditary exostosis

UR - http://www.scopus.com/inward/record.url?scp=34548406937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548406937&partnerID=8YFLogxK

U2 - 10.1097/BPB.0b013e32823ed01a

DO - 10.1097/BPB.0b013e32823ed01a

M3 - Article

C2 - 17762677

AN - SCOPUS:34548406937

VL - 16

SP - 363

EP - 365

JO - Journal of Pediatric Orthopaedics Part B

JF - Journal of Pediatric Orthopaedics Part B

SN - 1060-152X

IS - 5

ER -