TY - JOUR
T1 - Multiple effects induced by unstable mutation in streptomyces lavendulae
AU - Nakano, Michiko M.
AU - Ogawara, Hiroshi
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1980
Y1 - 1980
N2 - Arg mutants, isolated from Streptomyces lavendulae at unusually high frequencies, showed several phenotypic characteristics. The characteristics common to all arg mutants include: (1) repression of β-lactamase production, (2) inhibition of aerial mycelium formation, (3) development of acid pH, (4) low saturation density of growth in liquid culture, (5) a decrease in antibiotic production, (6) an increase in sensitivity to benzylpenicillin and (7) a decrease in production of pigment. These results suggest that the arg mutation concomitantly caused the depression of secondary metabolism in S. lavendulae.
AB - Arg mutants, isolated from Streptomyces lavendulae at unusually high frequencies, showed several phenotypic characteristics. The characteristics common to all arg mutants include: (1) repression of β-lactamase production, (2) inhibition of aerial mycelium formation, (3) development of acid pH, (4) low saturation density of growth in liquid culture, (5) a decrease in antibiotic production, (6) an increase in sensitivity to benzylpenicillin and (7) a decrease in production of pigment. These results suggest that the arg mutation concomitantly caused the depression of secondary metabolism in S. lavendulae.
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U2 - 10.7164/antibiotics.33.420
DO - 10.7164/antibiotics.33.420
M3 - Article
C2 - 6967867
AN - SCOPUS:0019119325
SN - 0021-8820
VL - 33
SP - 420
EP - 425
JO - the journal of antibiotics
JF - the journal of antibiotics
IS - 4
ER -