Multiple effects induced by unstable mutation in streptomyces lavendulae

Michiko M. Nakano, Hiroshi Ogawara

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Arg mutants, isolated from Streptomyces lavendulae at unusually high frequencies, showed several phenotypic characteristics. The characteristics common to all arg mutants include: (1) repression of β-lactamase production, (2) inhibition of aerial mycelium formation, (3) development of acid pH, (4) low saturation density of growth in liquid culture, (5) a decrease in antibiotic production, (6) an increase in sensitivity to benzylpenicillin and (7) a decrease in production of pigment. These results suggest that the arg mutation concomitantly caused the depression of secondary metabolism in S. lavendulae.

Original languageEnglish (US)
Pages (from-to)420-425
Number of pages6
Journalthe journal of antibiotics
Issue number4
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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