Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

Lisa Coussens, Peter J. Parker, Lucy Rhee, Teresa L. Yang-Feng, Ellson Chen, Michael D. Waterfield, Uta Francke, Axel Ullrich

Research output: Contribution to journalArticle

718 Scopus citations

Abstract

A new family of protein kinase C - related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
JournalScience
Volume233
Issue number4766
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • General

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    Coussens, L., Parker, P. J., Rhee, L., Yang-Feng, T. L., Chen, E., Waterfield, M. D., Francke, U., & Ullrich, A. (1986). Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science, 233(4766), 859-866. https://doi.org/10.1126/science.3755548