Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

Lisa Coussens, Peter J. Parker, Lucy Rhee, Teresa L. Yang-Feng, Ellson Chen, Michael D. Waterfield, Uta Francke, Axel Ullrich

Research output: Contribution to journalArticle

716 Citations (Scopus)

Abstract

A new family of protein kinase C - related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
JournalScience
Volume233
Issue number4766
StatePublished - 1986
Externally publishedYes

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Protein Kinase C
Genes
Human Chromosomes
Human Genome
Sequence Homology
Protein Kinases
Phosphotransferases
Binding Sites
Calcium

ASJC Scopus subject areas

  • General

Cite this

Coussens, L., Parker, P. J., Rhee, L., Yang-Feng, T. L., Chen, E., Waterfield, M. D., ... Ullrich, A. (1986). Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science, 233(4766), 859-866.

Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. / Coussens, Lisa; Parker, Peter J.; Rhee, Lucy; Yang-Feng, Teresa L.; Chen, Ellson; Waterfield, Michael D.; Francke, Uta; Ullrich, Axel.

In: Science, Vol. 233, No. 4766, 1986, p. 859-866.

Research output: Contribution to journalArticle

Coussens, L, Parker, PJ, Rhee, L, Yang-Feng, TL, Chen, E, Waterfield, MD, Francke, U & Ullrich, A 1986, 'Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways', Science, vol. 233, no. 4766, pp. 859-866.
Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD et al. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science. 1986;233(4766):859-866.
Coussens, Lisa ; Parker, Peter J. ; Rhee, Lucy ; Yang-Feng, Teresa L. ; Chen, Ellson ; Waterfield, Michael D. ; Francke, Uta ; Ullrich, Axel. / Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. In: Science. 1986 ; Vol. 233, No. 4766. pp. 859-866.
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