Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox

Erika Hammarlund, Matthew W. Lewis, Shirley V. Carter, Ian Amanna, Scott Hansen, Lisa I. Strelow, Scott Wong, Paul Yoshihara, Jon Hanifin, Mark Slifka

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Approximately 50% of the US population received smallpox vaccinations before routine immunization ceased in 1972 for civilians and in 1990 for military personnel. Several studies have shown long-term immunity after smallpox vaccination, but skepticism remains as to whether this will translate into full protection against the onset of orthopoxvirus-induced disease. The US monkeypox outbreak of 2003 provided the opportunity to examine this issue. Using independent and internally validated diagnostic approaches with ≥95% sensitivity and ≥90% specificity for detecting clinical monkeypox infection, we identified three previously unreported cases of monkeypox in preimmune individuals at 13, 29 and 48 years after smallpox vaccination. These individuals were unaware that they had been infected because they were spared any recognizable disease symptoms. Together, this shows that the US monkeypox outbreak was larger than previously realized and, more importantly, shows that cross-protective antiviral immunity against West African monkeypox can potentially be maintained for decades after smallpox vaccination.

Original languageEnglish (US)
Pages (from-to)1005-1011
Number of pages7
JournalNature Medicine
Volume11
Issue number9
DOIs
StatePublished - Sep 2005

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Monkeypox
Smallpox
Immunity
Immunization
Vaccination
Antiviral Agents
Personnel
Disease Outbreaks
Orthopoxvirus
Military Personnel
Sensitivity and Specificity
Infection
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. / Hammarlund, Erika; Lewis, Matthew W.; Carter, Shirley V.; Amanna, Ian; Hansen, Scott; Strelow, Lisa I.; Wong, Scott; Yoshihara, Paul; Hanifin, Jon; Slifka, Mark.

In: Nature Medicine, Vol. 11, No. 9, 09.2005, p. 1005-1011.

Research output: Contribution to journalArticle

Hammarlund, Erika ; Lewis, Matthew W. ; Carter, Shirley V. ; Amanna, Ian ; Hansen, Scott ; Strelow, Lisa I. ; Wong, Scott ; Yoshihara, Paul ; Hanifin, Jon ; Slifka, Mark. / Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox. In: Nature Medicine. 2005 ; Vol. 11, No. 9. pp. 1005-1011.
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