Abstract
Purpose: To present data to support the hypothesis that human retinoblastoma tumors form by a multistep process. Methods: Survey of the karyotype of 90 human retinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes. Conclusion: The data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other human malignancies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 299-314 |
| Number of pages | 16 |
| Journal | Transactions of the American Ophthalmological Society |
| Volume | 94 |
| State | Published - 1996 |
| Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology