Multiple changes in oncogenes and tumor suppressor genes in human retinoblastoma

R. O. Howard, D. M. Albert

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: To present data to support the hypothesis that human retinoblastoma tumors form by a multistep process. Methods: Survey of the karyotype of 90 human retinoblastomas, with emphasis on changes in chromosomal regions known to contain oncogenes and tumor suppressor genes. Conclusion: The data support the hypothesis that retinoblastoma occurs after multiple and often varied steps, similar to other human malignancies.

Original languageEnglish (US)
Pages (from-to)299-314
Number of pages16
JournalTransactions of the American Ophthalmological Society
Volume94
StatePublished - Dec 16 1996

ASJC Scopus subject areas

  • Ophthalmology

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