Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies

Bruce M. Coull, Dennis Bourdette, Scott H. Goodnight, Bruce M. Coull, Robert Hart

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Antibodies to negatively charged phospholipids including cardiolipin have been recognized in the sera of patients with systemic lupus erythematosus and other disorders. We report 4 patients who experienced cerebral infarctions and dementia in association with anticardiolipin antibodies. These patients did not have the characteristic lupus anticoagulant or systemic lupus erythematosus. The occurrence of anticardiolipin antibodies in patients with multiple cerebral infarctions who do not have evidence of a systemic vasculitis or inflammatory condition suggests that this association may be more common than previously recognized. It may be useful to test for the presence of anticardiolipin antibodies in patients who have unexplained cerebral infarctions.

Original languageEnglish (US)
Pages (from-to)1107-1112
Number of pages6
JournalStroke
Volume18
Issue number6
StatePublished - 1987

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Anticardiolipin Antibodies
Cerebral Infarction
Dementia
Systemic Lupus Erythematosus
Lupus Coagulation Inhibitor
Systemic Vasculitis
Cardiolipins
Phospholipids
Antibodies
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Coull, B. M., Bourdette, D., Goodnight, S. H., Coull, B. M., & Hart, R. (1987). Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. Stroke, 18(6), 1107-1112.

Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. / Coull, Bruce M.; Bourdette, Dennis; Goodnight, Scott H.; Coull, Bruce M.; Hart, Robert.

In: Stroke, Vol. 18, No. 6, 1987, p. 1107-1112.

Research output: Contribution to journalArticle

Coull, BM, Bourdette, D, Goodnight, SH, Coull, BM & Hart, R 1987, 'Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies', Stroke, vol. 18, no. 6, pp. 1107-1112.
Coull, Bruce M. ; Bourdette, Dennis ; Goodnight, Scott H. ; Coull, Bruce M. ; Hart, Robert. / Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. In: Stroke. 1987 ; Vol. 18, No. 6. pp. 1107-1112.
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