Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

Katherine A. Hoadley, Christina Yau, Denise M. Wolf, Andrew D. Cherniack, David Tamborero, Sam Ng, Max D M Leiserson, Beifang Niu, Michael D. McLellan, Vladislav Uzunangelov, Jiashan Zhang, Cyriac Kandoth, Rehan Akbani, Hui Shen, Larsson Omberg, Andy Chu, Adam Margolin, Laura J. Van'T Veer, Nuria Lopez-Bigas, Peter W. LairdBenjamin J. Raphael, Li Ding, A. Gordon Robertson, Lauren A. Byers, Gordon Mills, John N. Weinstein, Carter Van Waes, Zhong Chen, Eric A. Collisson, Christopher C. Benz, Charles M. Perou, Zheng Xia

Research output: Contribution to journalArticle

641 Citations (Scopus)

Abstract

Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue" disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)929-944
Number of pages16
JournalCell
Volume158
Issue number4
DOIs
StatePublished - Aug 14 2014

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Tissue
Urinary Bladder Neoplasms
Neoplasms
Genes
Data Mining
Proteomics
Amplification
Data mining
Tumors
Neck
Head
Genome
Lung
Therapeutics
Datasets

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. / Hoadley, Katherine A.; Yau, Christina; Wolf, Denise M.; Cherniack, Andrew D.; Tamborero, David; Ng, Sam; Leiserson, Max D M; Niu, Beifang; McLellan, Michael D.; Uzunangelov, Vladislav; Zhang, Jiashan; Kandoth, Cyriac; Akbani, Rehan; Shen, Hui; Omberg, Larsson; Chu, Andy; Margolin, Adam; Van'T Veer, Laura J.; Lopez-Bigas, Nuria; Laird, Peter W.; Raphael, Benjamin J.; Ding, Li; Robertson, A. Gordon; Byers, Lauren A.; Mills, Gordon; Weinstein, John N.; Van Waes, Carter; Chen, Zhong; Collisson, Eric A.; Benz, Christopher C.; Perou, Charles M.; Xia, Zheng.

In: Cell, Vol. 158, No. 4, 14.08.2014, p. 929-944.

Research output: Contribution to journalArticle

Hoadley, KA, Yau, C, Wolf, DM, Cherniack, AD, Tamborero, D, Ng, S, Leiserson, MDM, Niu, B, McLellan, MD, Uzunangelov, V, Zhang, J, Kandoth, C, Akbani, R, Shen, H, Omberg, L, Chu, A, Margolin, A, Van'T Veer, LJ, Lopez-Bigas, N, Laird, PW, Raphael, BJ, Ding, L, Robertson, AG, Byers, LA, Mills, G, Weinstein, JN, Van Waes, C, Chen, Z, Collisson, EA, Benz, CC, Perou, CM & Xia, Z 2014, 'Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin', Cell, vol. 158, no. 4, pp. 929-944. https://doi.org/10.1016/j.cell.2014.06.049
Hoadley, Katherine A. ; Yau, Christina ; Wolf, Denise M. ; Cherniack, Andrew D. ; Tamborero, David ; Ng, Sam ; Leiserson, Max D M ; Niu, Beifang ; McLellan, Michael D. ; Uzunangelov, Vladislav ; Zhang, Jiashan ; Kandoth, Cyriac ; Akbani, Rehan ; Shen, Hui ; Omberg, Larsson ; Chu, Andy ; Margolin, Adam ; Van'T Veer, Laura J. ; Lopez-Bigas, Nuria ; Laird, Peter W. ; Raphael, Benjamin J. ; Ding, Li ; Robertson, A. Gordon ; Byers, Lauren A. ; Mills, Gordon ; Weinstein, John N. ; Van Waes, Carter ; Chen, Zhong ; Collisson, Eric A. ; Benz, Christopher C. ; Perou, Charles M. ; Xia, Zheng. / Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. In: Cell. 2014 ; Vol. 158, No. 4. pp. 929-944.
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