Multimodal imaging in Wagner syndrome

Akshay S. Thomas, Kari Branham, Russell N. Van Gelder, Stephen P. Daiger, Lori S. Sullivan, Sara J. Bowne, John R. Heckenlively, Mark Pennesi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Wagner syndrome is a rare vitreoretinopathy described in a limited number of families. Here the authors describe four cases of suspected Wagner syndrome. All four cases had depressed rod and cone function on electroretinography, outer retinal disruption on spectral-domain optical coherence tomography, and constricted central visual fields with smaller isopter testing. Fundus autofluorescence performed in one patient highlighted a perivascular pattern to chorioretinal atrophy. Two patients had a history of uveitis with active cystoid macular edema. The diagnosis of Wagner syndrome was supported in three cases with genetic testing for VCAN mutations, whereas the other case harbored a variation of unknown significance in VCAN that may have been nonpathogenic.

Original languageEnglish (US)
Pages (from-to)574-579
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume47
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Multimodal Imaging
Electroretinography
Vertebrate Photoreceptor Cells
Macular Edema
Uveitis
Optical Coherence Tomography
Genetic Testing
Visual Fields
Atrophy
Mutation
Hyaloideoretinal degeneration of Wagner

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Thomas, A. S., Branham, K., Van Gelder, R. N., Daiger, S. P., Sullivan, L. S., Bowne, S. J., ... Pennesi, M. (2016). Multimodal imaging in Wagner syndrome. Ophthalmic Surgery Lasers and Imaging Retina, 47(6), 574-579. https://doi.org/10.3928/23258160-20160601-10

Multimodal imaging in Wagner syndrome. / Thomas, Akshay S.; Branham, Kari; Van Gelder, Russell N.; Daiger, Stephen P.; Sullivan, Lori S.; Bowne, Sara J.; Heckenlively, John R.; Pennesi, Mark.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 47, No. 6, 01.06.2016, p. 574-579.

Research output: Contribution to journalArticle

Thomas, AS, Branham, K, Van Gelder, RN, Daiger, SP, Sullivan, LS, Bowne, SJ, Heckenlively, JR & Pennesi, M 2016, 'Multimodal imaging in Wagner syndrome', Ophthalmic Surgery Lasers and Imaging Retina, vol. 47, no. 6, pp. 574-579. https://doi.org/10.3928/23258160-20160601-10
Thomas AS, Branham K, Van Gelder RN, Daiger SP, Sullivan LS, Bowne SJ et al. Multimodal imaging in Wagner syndrome. Ophthalmic Surgery Lasers and Imaging Retina. 2016 Jun 1;47(6):574-579. https://doi.org/10.3928/23258160-20160601-10
Thomas, Akshay S. ; Branham, Kari ; Van Gelder, Russell N. ; Daiger, Stephen P. ; Sullivan, Lori S. ; Bowne, Sara J. ; Heckenlively, John R. ; Pennesi, Mark. / Multimodal imaging in Wagner syndrome. In: Ophthalmic Surgery Lasers and Imaging Retina. 2016 ; Vol. 47, No. 6. pp. 574-579.
@article{bbe0531f4a984df1a992089ea6c56e79,
title = "Multimodal imaging in Wagner syndrome",
abstract = "Wagner syndrome is a rare vitreoretinopathy described in a limited number of families. Here the authors describe four cases of suspected Wagner syndrome. All four cases had depressed rod and cone function on electroretinography, outer retinal disruption on spectral-domain optical coherence tomography, and constricted central visual fields with smaller isopter testing. Fundus autofluorescence performed in one patient highlighted a perivascular pattern to chorioretinal atrophy. Two patients had a history of uveitis with active cystoid macular edema. The diagnosis of Wagner syndrome was supported in three cases with genetic testing for VCAN mutations, whereas the other case harbored a variation of unknown significance in VCAN that may have been nonpathogenic.",
author = "Thomas, {Akshay S.} and Kari Branham and {Van Gelder}, {Russell N.} and Daiger, {Stephen P.} and Sullivan, {Lori S.} and Bowne, {Sara J.} and Heckenlively, {John R.} and Mark Pennesi",
year = "2016",
month = "6",
day = "1",
doi = "10.3928/23258160-20160601-10",
language = "English (US)",
volume = "47",
pages = "574--579",
journal = "Ophthalmic Surgery Lasers and Imaging Retina",
issn = "2325-8160",
publisher = "Slack Incorporated",
number = "6",

}

TY - JOUR

T1 - Multimodal imaging in Wagner syndrome

AU - Thomas, Akshay S.

AU - Branham, Kari

AU - Van Gelder, Russell N.

AU - Daiger, Stephen P.

AU - Sullivan, Lori S.

AU - Bowne, Sara J.

AU - Heckenlively, John R.

AU - Pennesi, Mark

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Wagner syndrome is a rare vitreoretinopathy described in a limited number of families. Here the authors describe four cases of suspected Wagner syndrome. All four cases had depressed rod and cone function on electroretinography, outer retinal disruption on spectral-domain optical coherence tomography, and constricted central visual fields with smaller isopter testing. Fundus autofluorescence performed in one patient highlighted a perivascular pattern to chorioretinal atrophy. Two patients had a history of uveitis with active cystoid macular edema. The diagnosis of Wagner syndrome was supported in three cases with genetic testing for VCAN mutations, whereas the other case harbored a variation of unknown significance in VCAN that may have been nonpathogenic.

AB - Wagner syndrome is a rare vitreoretinopathy described in a limited number of families. Here the authors describe four cases of suspected Wagner syndrome. All four cases had depressed rod and cone function on electroretinography, outer retinal disruption on spectral-domain optical coherence tomography, and constricted central visual fields with smaller isopter testing. Fundus autofluorescence performed in one patient highlighted a perivascular pattern to chorioretinal atrophy. Two patients had a history of uveitis with active cystoid macular edema. The diagnosis of Wagner syndrome was supported in three cases with genetic testing for VCAN mutations, whereas the other case harbored a variation of unknown significance in VCAN that may have been nonpathogenic.

UR - http://www.scopus.com/inward/record.url?scp=84983735891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983735891&partnerID=8YFLogxK

U2 - 10.3928/23258160-20160601-10

DO - 10.3928/23258160-20160601-10

M3 - Article

C2 - 27327288

AN - SCOPUS:84983735891

VL - 47

SP - 574

EP - 579

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

SN - 2325-8160

IS - 6

ER -