TY - JOUR
T1 - Multicriteria decision analysis process to develop new classification criteria for systemic lupus erythematosus
AU - Tedeschi, Sara K.
AU - Johnson, Sindhu R.
AU - Boumpas, Dimitrios T.
AU - Daikh, David
AU - Dörner, Thomas
AU - Diamond, Betty
AU - Jacobsen, Søren
AU - Jayne, David
AU - Kamen, Diane L.
AU - McCune, W. Joseph
AU - Mosca, Marta
AU - Ramsey-Goldman, Rosalind
AU - Ruiz-Irastorza, Guillermo
AU - Schneider, Matthias
AU - Urowitz, Murray
AU - Wofsy, David
AU - Smolen, Josef S.
AU - Naden, Raymond P.
AU - Aringer, Martin
AU - Costenbader, Karen H.
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - European League Against Rheumatism and are jointly supporting multiphase development of systemic lupus erythematosus (SLE) classification criteria based on weighted criteria and a continuous probability scale. Prior steps included item generation, item reduction and hierarchical organisation of candidate criteria using an evidence-based approach. Our objectives were to determine relative weights using multicriteria decision analysis (MCDA) and to set a provisional threshold score for SLE classification. An SLE Expert Panel (8 European, 9 North American) submitted 164 real, unique cases with a wide range of SLE probability in a standardised format. Using the candidate criteria, experts scored and rank-ordered 20 representative cases. At an in-person meeting, experts reviewed inter-rater reliability of scoring, further refined criteria definitions and participated in an MCDA exercise. Based on expert consensus decisions on pairwise comparisons of criteria, 1000minds software calculated criteria weights and rank-ordered the remaining 144 cases based on their additive scores. The score of the lowest-ranked case for which complete expert consensus was achieved defined the provisional threshold classification score. Inter-rater reliability of scoring cases with the candidate criteria was good. MCDA involved 74 pairwise decisions and was repeated for the arthritis and mucocutaneous domains when the initial ranking of some cases did not match expert opinion. After criteria weights and additive scores were recalculated once, experts reached consensus for SLE classification for all cases scoring>83. Using an iterative process, the candidate criteria definitions were refined, preliminary weights were calculated and a provisional threshold score for SLE classification was determined.
AB - European League Against Rheumatism and are jointly supporting multiphase development of systemic lupus erythematosus (SLE) classification criteria based on weighted criteria and a continuous probability scale. Prior steps included item generation, item reduction and hierarchical organisation of candidate criteria using an evidence-based approach. Our objectives were to determine relative weights using multicriteria decision analysis (MCDA) and to set a provisional threshold score for SLE classification. An SLE Expert Panel (8 European, 9 North American) submitted 164 real, unique cases with a wide range of SLE probability in a standardised format. Using the candidate criteria, experts scored and rank-ordered 20 representative cases. At an in-person meeting, experts reviewed inter-rater reliability of scoring, further refined criteria definitions and participated in an MCDA exercise. Based on expert consensus decisions on pairwise comparisons of criteria, 1000minds software calculated criteria weights and rank-ordered the remaining 144 cases based on their additive scores. The score of the lowest-ranked case for which complete expert consensus was achieved defined the provisional threshold classification score. Inter-rater reliability of scoring cases with the candidate criteria was good. MCDA involved 74 pairwise decisions and was repeated for the arthritis and mucocutaneous domains when the initial ranking of some cases did not match expert opinion. After criteria weights and additive scores were recalculated once, experts reached consensus for SLE classification for all cases scoring>83. Using an iterative process, the candidate criteria definitions were refined, preliminary weights were calculated and a provisional threshold score for SLE classification was determined.
KW - Clinical research
KW - Methodology
KW - Systemic lupus erythematosus
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U2 - 10.1136/annrheumdis-2018-214685
DO - 10.1136/annrheumdis-2018-214685
M3 - Article
C2 - 30692164
AN - SCOPUS:85060674638
SN - 0003-4967
VL - 78
SP - 634
EP - 640
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 5
ER -