Multicentric reticulohistiocytosis and urologic carcinomas: A possible paraneoplastic association

Belinda H. Tan, Catherine I. Barry, Mark R. Wick, Kevin P. White, Jeffrey G. Brown, Abigail Lee, Amy H. Litchfield, Elizabeth V. Lener, Paul K. Shitabata

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Multicentric reticulohistiocytosis (MR) is a rare non-Langerhans histiocytosis that is characterized by cutaneous nodules and severe destructive arthritis. Although 25-30% of reported cases have been associated with internal malignancies, the pathophysiology of MR is unknown. Herein, we report two cases of MR that were associated with urologic neoplasms. Because the tumor suppressor gene p53 may play a role in the biology of other histiocytoses, we investigated its p53 immunoexpression in these two cases. Both cases were positive immunohistochemically, but it remains to be seen whether this finding is truly important in the pathogenesis of MR associated with underlying visceral neoplasms.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalJournal of cutaneous pathology
Issue number1
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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