Multicentric reticulohistiocytosis: A case report of an atypical presentation in a 2-year-old

Jaleh Olson, Julianne A. Mann, Kevin White, Victoria W. Cartwright, Jeremy Bauer, Dawn Nolt

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease marked by severe and often rapidly progressive polyarticular arthritis and cutaneous papulonodules. Initial clinical diagnosis may be difficult. We describe a 2-year-old girl presenting with pink dermal papules on the forehead, thighs, elbows, knees, and palms of the hands. Based on clinical findings and skin biopsy results, she was initially diagnosed with granuloma annulare. At 5 years of age, she developed arthritis, fatigue, and more widespread skin papules leading to the diagnosis of MRH. To our knowledge, this is the youngest individual with MRH yet described. We outline the timeline and unique features of her case and review the literature pertaining to MRH in children. Although rare, MRH can be permanently debilitating, making prompt diagnosis critical. A standardized approach to investigation and management needs to be developed.

Original languageEnglish (US)
Pages (from-to)e70-e73
JournalPediatric Dermatology
Volume32
Issue number3
DOIs
StatePublished - May 1 2015

Fingerprint

Skin
Arthritis
Granuloma Annulare
Forehead
Elbow
Thigh
Fatigue
Knee
Hand
Biopsy
TimeLine

ASJC Scopus subject areas

  • Dermatology
  • Pediatrics, Perinatology, and Child Health

Cite this

Multicentric reticulohistiocytosis : A case report of an atypical presentation in a 2-year-old. / Olson, Jaleh; Mann, Julianne A.; White, Kevin; Cartwright, Victoria W.; Bauer, Jeremy; Nolt, Dawn.

In: Pediatric Dermatology, Vol. 32, No. 3, 01.05.2015, p. e70-e73.

Research output: Contribution to journalArticle

Olson, Jaleh ; Mann, Julianne A. ; White, Kevin ; Cartwright, Victoria W. ; Bauer, Jeremy ; Nolt, Dawn. / Multicentric reticulohistiocytosis : A case report of an atypical presentation in a 2-year-old. In: Pediatric Dermatology. 2015 ; Vol. 32, No. 3. pp. e70-e73.
@article{a38286fa83524b78b13a45364389e8af,
title = "Multicentric reticulohistiocytosis: A case report of an atypical presentation in a 2-year-old",
abstract = "Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease marked by severe and often rapidly progressive polyarticular arthritis and cutaneous papulonodules. Initial clinical diagnosis may be difficult. We describe a 2-year-old girl presenting with pink dermal papules on the forehead, thighs, elbows, knees, and palms of the hands. Based on clinical findings and skin biopsy results, she was initially diagnosed with granuloma annulare. At 5 years of age, she developed arthritis, fatigue, and more widespread skin papules leading to the diagnosis of MRH. To our knowledge, this is the youngest individual with MRH yet described. We outline the timeline and unique features of her case and review the literature pertaining to MRH in children. Although rare, MRH can be permanently debilitating, making prompt diagnosis critical. A standardized approach to investigation and management needs to be developed.",
author = "Jaleh Olson and Mann, {Julianne A.} and Kevin White and Cartwright, {Victoria W.} and Jeremy Bauer and Dawn Nolt",
year = "2015",
month = "5",
day = "1",
doi = "10.1111/pde.12531",
language = "English (US)",
volume = "32",
pages = "e70--e73",
journal = "Pediatric Dermatology",
issn = "0736-8046",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Multicentric reticulohistiocytosis

T2 - A case report of an atypical presentation in a 2-year-old

AU - Olson, Jaleh

AU - Mann, Julianne A.

AU - White, Kevin

AU - Cartwright, Victoria W.

AU - Bauer, Jeremy

AU - Nolt, Dawn

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease marked by severe and often rapidly progressive polyarticular arthritis and cutaneous papulonodules. Initial clinical diagnosis may be difficult. We describe a 2-year-old girl presenting with pink dermal papules on the forehead, thighs, elbows, knees, and palms of the hands. Based on clinical findings and skin biopsy results, she was initially diagnosed with granuloma annulare. At 5 years of age, she developed arthritis, fatigue, and more widespread skin papules leading to the diagnosis of MRH. To our knowledge, this is the youngest individual with MRH yet described. We outline the timeline and unique features of her case and review the literature pertaining to MRH in children. Although rare, MRH can be permanently debilitating, making prompt diagnosis critical. A standardized approach to investigation and management needs to be developed.

AB - Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease marked by severe and often rapidly progressive polyarticular arthritis and cutaneous papulonodules. Initial clinical diagnosis may be difficult. We describe a 2-year-old girl presenting with pink dermal papules on the forehead, thighs, elbows, knees, and palms of the hands. Based on clinical findings and skin biopsy results, she was initially diagnosed with granuloma annulare. At 5 years of age, she developed arthritis, fatigue, and more widespread skin papules leading to the diagnosis of MRH. To our knowledge, this is the youngest individual with MRH yet described. We outline the timeline and unique features of her case and review the literature pertaining to MRH in children. Although rare, MRH can be permanently debilitating, making prompt diagnosis critical. A standardized approach to investigation and management needs to be developed.

UR - http://www.scopus.com/inward/record.url?scp=84929706125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929706125&partnerID=8YFLogxK

U2 - 10.1111/pde.12531

DO - 10.1111/pde.12531

M3 - Article

C2 - 25727569

AN - SCOPUS:84929706125

VL - 32

SP - e70-e73

JO - Pediatric Dermatology

JF - Pediatric Dermatology

SN - 0736-8046

IS - 3

ER -