Multicenter study of QuantiFERON®-TB Gold Plus in patients with active tuberculosis

D. J. Horne, B. E. Jones, A. Kamada, K. Fukushima, K. L. Winthrop, S. A.R. Siegel, A. Kovacs, P. Anthony, K. A. Meekin, S. Bhat, P. Kerndt, A. Chang, D. M. Koelle, M. Narita

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Setting: QuantiFERONw-TB Gold Plus (QFT-Plus), recently approved for use in the United States, is a newgeneration QuantiFERON assay that differs from its predecessors in that it uses an additional antigen tube containing peptides to elicit both CD8 + and CD4 + Tlymphocyte responses. Objective : To assess the sensitivity of QFT-Plus compared with QuantiFERON®-TB Gold In-Tube (QFT-GIT) in participants with active TB. Design: Adult patients with active TB at three US and two Japanese sites were eligible for this study if they had culture-confirmed TB and were either untreated or had received ≤14 days of anti-tuberculosis treatment. Results : We enrolled 164 participants, nine of whom had indeterminate results. Excluding indeterminate values, there were 150 QFT-GIT-positive results among 159 tests and 146 QFT-Plus-positive results among 157 tests, with sensitivities of respectively 94.3% (95%CI 89.5-97.4) and 93.02% (95%CI 87.8-96.5%). The estimated sensitivities for the two tests were not significantly different (P=0.16). Overall test agreement was 98.7%, with a κ statistic of 0.89 (95%CI 0.75-1.00). Conclusion: In this multisite study, we found that QFT-Plus had similar sensitivity to QFT-GIT in adult patients with active TB.

Original languageEnglish (US)
Pages (from-to)617-621
Number of pages5
JournalInternational Journal of Tuberculosis and Lung Disease
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2018

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Keywords

  • Diagnosis
  • Epidemiology
  • Latent tuberculous infection
  • Test discordance

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Horne, D. J., Jones, B. E., Kamada, A., Fukushima, K., Winthrop, K. L., Siegel, S. A. R., Kovacs, A., Anthony, P., Meekin, K. A., Bhat, S., Kerndt, P., Chang, A., Koelle, D. M., & Narita, M. (2018). Multicenter study of QuantiFERON®-TB Gold Plus in patients with active tuberculosis. International Journal of Tuberculosis and Lung Disease, 22(6), 617-621. https://doi.org/10.5588/ijtld.17.0721