Multi-centre validation of the prognostic value of the haematopoietic cell transplantation- specific comorbidity index among recipient of allogeneic haematopoietic cell transplantation

Mahmoud Elsawy, Barry E. Storer, Michael A. Pulsipher, Richard T. Maziarz, Smita Bhatia, Michael B. Maris, Karen L. Syrjala, Paul J. Martin, David G. Maloney, Brenda M. Sandmaier, Rainer Storb, Mohamed L. Sorror

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The haematopoietic cell transplantation-specific comorbidity index (HCT-CI) was developed in a single centre as a weighted scoring system to predict risks of non-relapse mortality (NRM) following allogeneic haematopoietic cell transplantation. Information on the performance of the HCT-CI in multi-centre studies is lacking in the literature. To that end, a collaborative multicentre retrospective study was initiated. Comorbidity data from 2523 consecutive recipients of human leucocyte antigen-matched grafts from five different US institutions were analysed. Among all patients, HCT-CI scores of 0 vs. 1-2 vs. ≥3 were associated with 2-year NRM rates of 14%, 23% and 39% (P < 0·0001), respectively, and 2-year overall survival (OS) rates of 74%, 61% and 39%, respectively (P < 0·0001). Using regression models, increasing HCT-CI scores were independently associated with increases in hazard ratios for NRM and worse survival within individual institutions. The HCT-CI retained independent capacity for association with outcomes within different age as well as conditioning intensity groups. C-statistic estimates for the prognostic power of the HCT-CI for NRM and OS were 0·66 and 0·64, respectively. The estimates within each institution were overall similar. The HCT-CI is a valid tool for capturing comorbidities and predicting mortality after haematopoietic cell transplantation across different institutions.

Original languageEnglish (US)
Pages (from-to)574-583
Number of pages10
JournalBritish Journal of Haematology
Volume170
Issue number4
DOIs
StatePublished - Aug 1 2015

Keywords

  • Allogeneic
  • Comorbidities
  • HCT-CI
  • Haematopoietic cell transplantation
  • Validation

ASJC Scopus subject areas

  • Hematology

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