mTOR and cancer: Reason for dancing at the crossroads?

George V. Thomas

doi:10.1016/j.gde.2005.12.003

mTOR and cancer: Reason for dancing at the crossroads?

George V. Thomas

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

Recent successes using Gleevec for the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors have provided proof that strategies to target signal transduction pathways mutated in human cancers can work. However, the application of this strategy to other cancers has been slow. Central to alleviating this impedance is the molecular characterization of the tumors. There is an urgent need to translate basic scientific findings into relevant, clinically applicable molecular diagnostic assays.

Original language	English (US)
Pages (from-to)	78-84
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.gde.2005.12.003
State	Published - Feb 2006
Externally published	Yes

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2005.12.003

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title = "mTOR and cancer: Reason for dancing at the crossroads?",

abstract = "Recent successes using Gleevec for the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors have provided proof that strategies to target signal transduction pathways mutated in human cancers can work. However, the application of this strategy to other cancers has been slow. Central to alleviating this impedance is the molecular characterization of the tumors. There is an urgent need to translate basic scientific findings into relevant, clinically applicable molecular diagnostic assays.",

author = "Thomas, {George V.}",

note = "Funding Information: I thank Charles Sawyers for the science; Ingo Mellinghoff for helpful discussions; Moya Costello for graphics support. My work is supported by grants from the NCI–UCLA Prostate SPORE, US Department of Defense, University of California Cancer Research Coordinating Committee, the Stein-Oppenheimer Family Endowment and the Wendy Will Case Foundation. I am also indebted to Jonathan Braun for the academic and research support.",

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N1 - Funding Information: I thank Charles Sawyers for the science; Ingo Mellinghoff for helpful discussions; Moya Costello for graphics support. My work is supported by grants from the NCI–UCLA Prostate SPORE, US Department of Defense, University of California Cancer Research Coordinating Committee, the Stein-Oppenheimer Family Endowment and the Wendy Will Case Foundation. I am also indebted to Jonathan Braun for the academic and research support.

PY - 2006/2

Y1 - 2006/2

N2 - Recent successes using Gleevec for the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors have provided proof that strategies to target signal transduction pathways mutated in human cancers can work. However, the application of this strategy to other cancers has been slow. Central to alleviating this impedance is the molecular characterization of the tumors. There is an urgent need to translate basic scientific findings into relevant, clinically applicable molecular diagnostic assays.

AB - Recent successes using Gleevec for the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors have provided proof that strategies to target signal transduction pathways mutated in human cancers can work. However, the application of this strategy to other cancers has been slow. Central to alleviating this impedance is the molecular characterization of the tumors. There is an urgent need to translate basic scientific findings into relevant, clinically applicable molecular diagnostic assays.

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mTOR and cancer: Reason for dancing at the crossroads?

Abstract

ASJC Scopus subject areas

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