MRS in relation to hippocampal volume in the oldest old

David C. Spencer, Tracy Zitzelberger, Daniel Spielman, Jeffrey Kaye

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.

Original languageEnglish (US)
Pages (from-to)1194-1196
Number of pages3
Issue number7
StatePublished - Apr 8 2003

ASJC Scopus subject areas

  • Clinical Neurology


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