MRS in relation to hippocampal volume in the oldest old

David C. Spencer; Tracy Zitzelberger; Daniel Spielman; Jeffrey Kaye

doi:10.1212/01.WNL.0000052822.22994.86

MRS in relation to hippocampal volume in the oldest old

David C. Spencer, Tracy Zitzelberger, Daniel Spielman, Jeffrey Kaye

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.

Original language	English (US)
Pages (from-to)	1194-1196
Number of pages	3
Journal	Neurology
Volume	60
Issue number	7
DOIs	https://doi.org/10.1212/01.WNL.0000052822.22994.86
State	Published - Apr 8 2003

ASJC Scopus subject areas

Clinical Neurology

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10.1212/01.WNL.0000052822.22994.86

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AB - The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.

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JO - Neurology

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MRS in relation to hippocampal volume in the oldest old

Abstract

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