MRS in relation to hippocampal volume in the oldest old

David Spencer, Tracy Zitzelberger, Daniel Spielman, Jeffrey Kaye

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.

Original languageEnglish (US)
Pages (from-to)1194-1196
Number of pages3
JournalNeurology
Volume60
Issue number7
StatePublished - Apr 8 2003

Fingerprint

Parietal Lobe
Inositol
Temporal Lobe
Dementia
Neuropsychological Tests
Healthy Volunteers
Biomarkers
Genotype
Brain
N-acetylaspartate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spencer, D., Zitzelberger, T., Spielman, D., & Kaye, J. (2003). MRS in relation to hippocampal volume in the oldest old. Neurology, 60(7), 1194-1196.

MRS in relation to hippocampal volume in the oldest old. / Spencer, David; Zitzelberger, Tracy; Spielman, Daniel; Kaye, Jeffrey.

In: Neurology, Vol. 60, No. 7, 08.04.2003, p. 1194-1196.

Research output: Contribution to journalArticle

Spencer, D, Zitzelberger, T, Spielman, D & Kaye, J 2003, 'MRS in relation to hippocampal volume in the oldest old', Neurology, vol. 60, no. 7, pp. 1194-1196.
Spencer D, Zitzelberger T, Spielman D, Kaye J. MRS in relation to hippocampal volume in the oldest old. Neurology. 2003 Apr 8;60(7):1194-1196.
Spencer, David ; Zitzelberger, Tracy ; Spielman, Daniel ; Kaye, Jeffrey. / MRS in relation to hippocampal volume in the oldest old. In: Neurology. 2003 ; Vol. 60, No. 7. pp. 1194-1196.
@article{fa55f98a72b349739af452b120ed23d9,
title = "MRS in relation to hippocampal volume in the oldest old",
abstract = "The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.",
author = "David Spencer and Tracy Zitzelberger and Daniel Spielman and Jeffrey Kaye",
year = "2003",
month = "4",
day = "8",
language = "English (US)",
volume = "60",
pages = "1194--1196",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - MRS in relation to hippocampal volume in the oldest old

AU - Spencer, David

AU - Zitzelberger, Tracy

AU - Spielman, Daniel

AU - Kaye, Jeffrey

PY - 2003/4/8

Y1 - 2003/4/8

N2 - The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.

AB - The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. MRS was used to study medial temporal and parietal regions in 60 cognitively healthy subjects older than 85 years. Subjects with small hippocampal volumes, a putative risk factor for dementia, had significantly lower NAA/mI in parietal and temporal lobes compared with other subjects. Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk.

UR - http://www.scopus.com/inward/record.url?scp=0037426391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037426391&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 1194

EP - 1196

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 7

ER -