Abstract
Localized translation and the requisite trafficking of the mRNA template play significant roles in the nervous system including the establishment of dendrites and axons, axon path-finding, and synaptic plasticity. We provide a brief review on the regulation of localizing mRNA in mammalian neurons through critical post-translational modifications of the factors involved. These examples highlight the relationship between mRNA trafficking and the translational regulation of trafficked mRNAs and provide insight into how extracellular signals target these events during signal transduction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 663-670 |
| Number of pages | 8 |
| Journal | Acta Biochimica et Biophysica Sinica |
| Volume | 43 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2011 |
| Externally published | Yes |
Keywords
- RNA binding proteins
- local translation
- mRNA trafficking
- post-transcriptional regulation
ASJC Scopus subject areas
- Molecular Biology
- Biophysics
- Biochemistry