MRNA trafficking and local translation: The Yin and Yang of regulating mRNA localization in neurons

John R. Sinnamon, Kevin Czaplinski

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Localized translation and the requisite trafficking of the mRNA template play significant roles in the nervous system including the establishment of dendrites and axons, axon path-finding, and synaptic plasticity. We provide a brief review on the regulation of localizing mRNA in mammalian neurons through critical post-translational modifications of the factors involved. These examples highlight the relationship between mRNA trafficking and the translational regulation of trafficked mRNAs and provide insight into how extracellular signals target these events during signal transduction.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalActa Biochimica et Biophysica Sinica
Volume43
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • RNA binding proteins
  • local translation
  • mRNA trafficking
  • post-transcriptional regulation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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