Mri of infiltrative lung disease

Comparison with pathologic findings

Steven Primack, John R. Mayo, Thomas E. Hartman, Roberta R. Miller, Nestor L. Müller

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective: Our goal was to compare MRI with pathologic findings in patients with chronic infiltrative lung disease. Materials and Methods: The study included 22 consecutive patients who had MRI and lung biopsy performed within 21 days (median 4 days). Fifteen patients had open lung biopsy: Five with idiopathic pulmonary fibrosis, three with extrinsic allergic alveolitis, and seven with miscellaneous conditions. Seven patients had transbronchial biopsy: four with sarcoidosis and three with miscellaneous conditions. All patients had 1.5 T MRI with cardiac-gated T1-, proton density-, and T2-weighted SE sequences. Results: The predominant patterns of abnormality seen on MR included parenchymal opacification (n = 12), parenchymal opacification and reticulation (n = 2), reticulation (n = 3), nodularity (n = 3), and interlobular septal thickening (n = 1); normal findings were found in 1. The 14 patients with parenchymal opacification included 9 with ground-glass intensity and 5 with consolidation. In 12 of these 14 patients the parenchymal opacification represented an active inflammatory process including alveolitis, pneumonia, and granulomatous inflammation, while in 2 patients it represented fibrosis. Reticulation was shown to represent fibrosis in five of five cases. The three patients with nodules had sarcoidosis. Conclusion: The MR findings correlate closely with those seen on lung bi-opsy. Parenchymal opacification on MR usually indicates the presence of potentially reversible disease, while reticulation usually indicates irreversible fibrosis.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume18
Issue number2
StatePublished - 1994
Externally publishedYes

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Lung Diseases
Fibrosis
Sarcoidosis
Biopsy
Lung
Extrinsic Allergic Alveolitis
Idiopathic Pulmonary Fibrosis
Glass
Protons
Pneumonia
Inflammation

Keywords

  • Diseases
  • Lungs
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Primack, S., Mayo, J. R., Hartman, T. E., Miller, R. R., & Müller, N. L. (1994). Mri of infiltrative lung disease: Comparison with pathologic findings. Journal of Computer Assisted Tomography, 18(2), 233-238.

Mri of infiltrative lung disease : Comparison with pathologic findings. / Primack, Steven; Mayo, John R.; Hartman, Thomas E.; Miller, Roberta R.; Müller, Nestor L.

In: Journal of Computer Assisted Tomography, Vol. 18, No. 2, 1994, p. 233-238.

Research output: Contribution to journalArticle

Primack, S, Mayo, JR, Hartman, TE, Miller, RR & Müller, NL 1994, 'Mri of infiltrative lung disease: Comparison with pathologic findings', Journal of Computer Assisted Tomography, vol. 18, no. 2, pp. 233-238.
Primack, Steven ; Mayo, John R. ; Hartman, Thomas E. ; Miller, Roberta R. ; Müller, Nestor L. / Mri of infiltrative lung disease : Comparison with pathologic findings. In: Journal of Computer Assisted Tomography. 1994 ; Vol. 18, No. 2. pp. 233-238.
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