MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis

Marielle C. Gold, Ruth J. Napier, David M. Lewinsohn

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

The intracellular pathogen Mycobacterium tuberculosis (Mtb) and its human host have long co-evolved. Although the host cellular immune response is critical to the control of the bacterium information on the specific contribution of different immune cell subsets in humans is incomplete. Mucosal associated invariant T (MAIT) cells are a prevalent and unique T-cell population in humans with the capacity to detect intracellular infection with bacteria including Mtb. MAIT cells detect bacterially derived metabolites presented by the evolutionarily conserved major histocompatibility complex-like molecule MR1. Here, we review recent advances in our understanding of this T-cell subset and address the potential roles for MR1-restricted T cells in the control, diagnosis, and therapy of tuberculosis.

Original languageEnglish (US)
Pages (from-to)154-166
Number of pages13
JournalImmunological reviews
Volume264
Issue number1
DOIs
StatePublished - Mar 1 2015

Keywords

  • MR1
  • Mucosal associated invariant T cells (MAIT)
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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