MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis

Se Jin Kim, Elham Karamooz

Research output: Contribution to journalReview articlepeer-review

Abstract

MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection.

Original languageEnglish (US)
Article number14412
JournalInternational journal of molecular sciences
Volume23
Issue number22
DOIs
StatePublished - Nov 2022

Keywords

  • antigen presentation
  • immunology
  • mycobacteria

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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