MR imaging of tumor-associated macrophages

Heike Daldrup-Link, Lisa Coussens

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Tumor associated macrophages (TAMs) in breast cancers foster several aspects of tumor progression and metastasis, and represent a biomarker associated with an unfavorable clinical outcome. As new therapeutic agents selectively targeting leukocytes enter the clinic whose mechanism of action involves diminishing macrophage infiltration or presence in tumors, it becomes increasingly important to identify those tumors heavily infiltrated by TAMs, as well as monitoring TAM response to therapy. MR imaging with iron oxide nanoparticles enables noninvasive quantification of TAMs in tumors, and thus, provides an easily accessible ex vivo assessment of TAMs for prognosis and related treatment decisions.

Original languageEnglish (US)
Pages (from-to)507-509
Number of pages3
JournalOncoImmunology
Volume1
Issue number4
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Macrophages
Neoplasms
Nanoparticles
Leukocytes
Biomarkers
Breast Neoplasms
Neoplasm Metastasis
Therapeutics

Keywords

  • Cellular imaging
  • Contrast agents
  • Magnetic resonance imaging
  • Nanoparticles
  • Tumor associated macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

MR imaging of tumor-associated macrophages. / Daldrup-Link, Heike; Coussens, Lisa.

In: OncoImmunology, Vol. 1, No. 4, 2012, p. 507-509.

Research output: Contribution to journalArticle

Daldrup-Link, Heike ; Coussens, Lisa. / MR imaging of tumor-associated macrophages. In: OncoImmunology. 2012 ; Vol. 1, No. 4. pp. 507-509.
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