TY - JOUR
T1 - MR imaging-based multimodal autoidentification of perivascular spaces (mMAPS)
T2 - Automated morphologic segmentation of enlarged perivascular spaces at clinical field strength
AU - Boespflug, Erin L.
AU - Schwartz, Daniel L.
AU - Lahna, David
AU - Pollock, Jeffrey
AU - Iliff, Jeffrey J.
AU - Kaye, Jeffrey A.
AU - Rooney, William
AU - Silbert, Lisa C.
N1 - Funding Information:
Supported by National Institutes of Health (1RO1AG036772, P30 AG008017, P30 AG024978, R01 AG042191, RO1 AG024059, S10 OD018224, S10 RR027694), the NIA/ Layton Oregon Aging & Alzheimer’s Disease Center, Paul G. Allen Foundation, and VA Merit Review.
PY - 2018/2
Y1 - 2018/2
N2 - Purpose: To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0- T) magnetic resonance (MR) imaging data. Materials and Methods: In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2- weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster. Visual rating was performed by three raters, including one neuroradiologist, after established singlesection guidelines. Correlations between visual counts and automated counts, as well session-to-session correlation of counts within each participant, were assessed with the Pearson correlation coefficient r. Results: There was a significant correlation between counts by visual raters and automated detection of ePVSs in the same section (r = 0.65, P , .001; r = 0.69, P , .001; and r = 0.54, P , .01 for raters 1, 2, and 3, respectively). With regard to visual ratings and whole-brain count consistency, average visual rating scores were highly correlated with automated detection of total burden volume (r = 0.58, P , .01) and total ePVS number (r = 0.76, P , .01). Morphology of clusters across 28 data sets was consistent with published radiographic estimates of ePVS; mean width of clusters segmented was 3.12 mm (range, 1.7-13.5 mm). Conclusion: This MR imaging-based method for multimodal autoidentification of perivascular spaces yields individual wholebrain morphologic characterization of ePVS in clinical MR imaging data and is an important tool in the detailed assessment of these features.
AB - Purpose: To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0- T) magnetic resonance (MR) imaging data. Materials and Methods: In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2- weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster. Visual rating was performed by three raters, including one neuroradiologist, after established singlesection guidelines. Correlations between visual counts and automated counts, as well session-to-session correlation of counts within each participant, were assessed with the Pearson correlation coefficient r. Results: There was a significant correlation between counts by visual raters and automated detection of ePVSs in the same section (r = 0.65, P , .001; r = 0.69, P , .001; and r = 0.54, P , .01 for raters 1, 2, and 3, respectively). With regard to visual ratings and whole-brain count consistency, average visual rating scores were highly correlated with automated detection of total burden volume (r = 0.58, P , .01) and total ePVS number (r = 0.76, P , .01). Morphology of clusters across 28 data sets was consistent with published radiographic estimates of ePVS; mean width of clusters segmented was 3.12 mm (range, 1.7-13.5 mm). Conclusion: This MR imaging-based method for multimodal autoidentification of perivascular spaces yields individual wholebrain morphologic characterization of ePVS in clinical MR imaging data and is an important tool in the detailed assessment of these features.
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U2 - 10.1148/radiol.2017170205
DO - 10.1148/radiol.2017170205
M3 - Article
C2 - 28853674
AN - SCOPUS:85041453379
SN - 0033-8419
VL - 286
SP - 632
EP - 642
JO - RADIOLOGY
JF - RADIOLOGY
IS - 2
ER -