MR imaging-based multimodal autoidentification of perivascular spaces (mMAPS): Automated morphologic segmentation of enlarged perivascular spaces at clinical field strength

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0- T) magnetic resonance (MR) imaging data. Materials and Methods: In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2- weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster. Visual rating was performed by three raters, including one neuroradiologist, after established singlesection guidelines. Correlations between visual counts and automated counts, as well session-to-session correlation of counts within each participant, were assessed with the Pearson correlation coefficient r. Results: There was a significant correlation between counts by visual raters and automated detection of ePVSs in the same section (r = 0.65, P , .001; r = 0.69, P , .001; and r = 0.54, P , .01 for raters 1, 2, and 3, respectively). With regard to visual ratings and whole-brain count consistency, average visual rating scores were highly correlated with automated detection of total burden volume (r = 0.58, P , .01) and total ePVS number (r = 0.76, P , .01). Morphology of clusters across 28 data sets was consistent with published radiographic estimates of ePVS; mean width of clusters segmented was 3.12 mm (range, 1.7-13.5 mm). Conclusion: This MR imaging-based method for multimodal autoidentification of perivascular spaces yields individual wholebrain morphologic characterization of ePVS in clinical MR imaging data and is an important tool in the detailed assessment of these features.

Original languageEnglish (US)
Pages (from-to)632-642
Number of pages11
JournalRadiology
Volume286
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Magnetic Resonance Imaging
Health Insurance Portability and Accountability Act
Informed Consent
Dementia
Protons
Magnetic Resonance Spectroscopy
Guidelines
Brain
Research

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{c9d01b8e630343f9acc07bac260b36df,
title = "MR imaging-based multimodal autoidentification of perivascular spaces (mMAPS): Automated morphologic segmentation of enlarged perivascular spaces at clinical field strength",
abstract = "Purpose: To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0- T) magnetic resonance (MR) imaging data. Materials and Methods: In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2- weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster. Visual rating was performed by three raters, including one neuroradiologist, after established singlesection guidelines. Correlations between visual counts and automated counts, as well session-to-session correlation of counts within each participant, were assessed with the Pearson correlation coefficient r. Results: There was a significant correlation between counts by visual raters and automated detection of ePVSs in the same section (r = 0.65, P , .001; r = 0.69, P , .001; and r = 0.54, P , .01 for raters 1, 2, and 3, respectively). With regard to visual ratings and whole-brain count consistency, average visual rating scores were highly correlated with automated detection of total burden volume (r = 0.58, P , .01) and total ePVS number (r = 0.76, P , .01). Morphology of clusters across 28 data sets was consistent with published radiographic estimates of ePVS; mean width of clusters segmented was 3.12 mm (range, 1.7-13.5 mm). Conclusion: This MR imaging-based method for multimodal autoidentification of perivascular spaces yields individual wholebrain morphologic characterization of ePVS in clinical MR imaging data and is an important tool in the detailed assessment of these features.",
author = "Erin Boespflug and Schwartz, {Daniel L.} and David Lahna and Jeffrey Pollock and Jeffrey Iliff and Jeffrey Kaye and William Rooney and Lisa Silbert",
year = "2018",
month = "2",
day = "1",
doi = "10.1148/radiol.2017170205",
language = "English (US)",
volume = "286",
pages = "632--642",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - MR imaging-based multimodal autoidentification of perivascular spaces (mMAPS)

T2 - Automated morphologic segmentation of enlarged perivascular spaces at clinical field strength

AU - Boespflug, Erin

AU - Schwartz, Daniel L.

AU - Lahna, David

AU - Pollock, Jeffrey

AU - Iliff, Jeffrey

AU - Kaye, Jeffrey

AU - Rooney, William

AU - Silbert, Lisa

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose: To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0- T) magnetic resonance (MR) imaging data. Materials and Methods: In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2- weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster. Visual rating was performed by three raters, including one neuroradiologist, after established singlesection guidelines. Correlations between visual counts and automated counts, as well session-to-session correlation of counts within each participant, were assessed with the Pearson correlation coefficient r. Results: There was a significant correlation between counts by visual raters and automated detection of ePVSs in the same section (r = 0.65, P , .001; r = 0.69, P , .001; and r = 0.54, P , .01 for raters 1, 2, and 3, respectively). With regard to visual ratings and whole-brain count consistency, average visual rating scores were highly correlated with automated detection of total burden volume (r = 0.58, P , .01) and total ePVS number (r = 0.76, P , .01). Morphology of clusters across 28 data sets was consistent with published radiographic estimates of ePVS; mean width of clusters segmented was 3.12 mm (range, 1.7-13.5 mm). Conclusion: This MR imaging-based method for multimodal autoidentification of perivascular spaces yields individual wholebrain morphologic characterization of ePVS in clinical MR imaging data and is an important tool in the detailed assessment of these features.

AB - Purpose: To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0- T) magnetic resonance (MR) imaging data. Materials and Methods: In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2- weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster. Visual rating was performed by three raters, including one neuroradiologist, after established singlesection guidelines. Correlations between visual counts and automated counts, as well session-to-session correlation of counts within each participant, were assessed with the Pearson correlation coefficient r. Results: There was a significant correlation between counts by visual raters and automated detection of ePVSs in the same section (r = 0.65, P , .001; r = 0.69, P , .001; and r = 0.54, P , .01 for raters 1, 2, and 3, respectively). With regard to visual ratings and whole-brain count consistency, average visual rating scores were highly correlated with automated detection of total burden volume (r = 0.58, P , .01) and total ePVS number (r = 0.76, P , .01). Morphology of clusters across 28 data sets was consistent with published radiographic estimates of ePVS; mean width of clusters segmented was 3.12 mm (range, 1.7-13.5 mm). Conclusion: This MR imaging-based method for multimodal autoidentification of perivascular spaces yields individual wholebrain morphologic characterization of ePVS in clinical MR imaging data and is an important tool in the detailed assessment of these features.

UR - http://www.scopus.com/inward/record.url?scp=85041453379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041453379&partnerID=8YFLogxK

U2 - 10.1148/radiol.2017170205

DO - 10.1148/radiol.2017170205

M3 - Article

VL - 286

SP - 632

EP - 642

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -