Mpdz is a quantitative trait gene for drug withdrawal seizures

Renee L. Shirley, Nicole A R Walter, Matthew T. Reilly, Christoph Fehr, Kari Buck

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.

Original languageEnglish (US)
Pages (from-to)699-700
Number of pages2
JournalNature Neuroscience
Volume7
Issue number7
DOIs
StatePublished - Jul 2004

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Substance-Related Disorders
Seizures
Pharmaceutical Preparations
Genes
PDZ Domains
Gene Regulatory Networks
Sequence Analysis
Organism Cloning
Proteins
Recurrence

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Shirley, R. L., Walter, N. A. R., Reilly, M. T., Fehr, C., & Buck, K. (2004). Mpdz is a quantitative trait gene for drug withdrawal seizures. Nature Neuroscience, 7(7), 699-700. https://doi.org/10.1038/nn1271

Mpdz is a quantitative trait gene for drug withdrawal seizures. / Shirley, Renee L.; Walter, Nicole A R; Reilly, Matthew T.; Fehr, Christoph; Buck, Kari.

In: Nature Neuroscience, Vol. 7, No. 7, 07.2004, p. 699-700.

Research output: Contribution to journalArticle

Shirley, RL, Walter, NAR, Reilly, MT, Fehr, C & Buck, K 2004, 'Mpdz is a quantitative trait gene for drug withdrawal seizures', Nature Neuroscience, vol. 7, no. 7, pp. 699-700. https://doi.org/10.1038/nn1271
Shirley, Renee L. ; Walter, Nicole A R ; Reilly, Matthew T. ; Fehr, Christoph ; Buck, Kari. / Mpdz is a quantitative trait gene for drug withdrawal seizures. In: Nature Neuroscience. 2004 ; Vol. 7, No. 7. pp. 699-700.
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