Mpdz is a quantitative trait gene for drug withdrawal seizures

Renee L. Shirley, Nicole A.R. Walter, Matthew T. Reilly, Christoph Fehr, Kari J. Buck

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.

Original languageEnglish (US)
Pages (from-to)699-700
Number of pages2
JournalNature Neuroscience
Issue number7
StatePublished - Jul 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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