Mouse models for human otitis media

Dennis R. Trune, Qing Yin Zheng

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Otitis media (OM) remains the most common childhood disease and its annual costs exceed $5 billion. Its potential for permanent hearing impairment also emphasizes the need to better understand and manage this disease. The pathogenesis of OM is multifactorial and includes infectious pathogens, anatomy, immunologic status, genetic predisposition, and environment. Recent progress in mouse model development is helping to elucidate the respective roles of these factors and to significantly contribute toward efforts of OM prevention and control. Genetic predisposition is recognized as an important factor in OM and increasing numbers of mouse models are helping to uncover the potential genetic bases for human OM. Furthermore, the completion of the mouse genome sequence has offered a powerful set of tools for investigating gene function and is generating a rich resource of mouse mutants for studying the genetic factors underlying OM.

Original languageEnglish (US)
Pages (from-to)90-103
Number of pages14
JournalBrain research
StatePublished - Jun 24 2009


  • Etiology
  • Genetic predisposition to disease
  • Immunology
  • Mice
  • Otitis media

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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