Mouse lines selected for alcohol consumption differ on certain measures of impulsivity

Clare Wilhelm, Jamie M. Reeves, Tamara Phillips, Suzanne Mitchell

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Alcoholics and heavy drinkers score higher on measures of impulsivity than nonalcoholics and light drinkers. This may be due to factors that predate drug exposure (e.g. genetics) or to neuroadaptations associated with exposure to alcohol. The aim of this study was to examine the role of genetics by comparing impulsivity in short-term selected lines of mice bred to voluntarily drink either high (STDRHI2) or low (STDRLO2) amounts of 10% ethanol. Methods: Independent sets of mice completed 2 experiments designed to measure impulsivity. Using the adjusting amount procedure, we examined preference for smaller, sooner rewards over larger but delayed rewards (delay discounting). This task determines the amount of immediate sucrose equivalent to the discounted value of a 20 μl sucrose reward given following a specific delay (0, 2, 4, 8, or 12 seconds). Using a Go/No-go task, we examined the ability of mice to inhibit nose-poking in response to specific cues. These tasks are commonly used to assess different aspects of impulsive behavior, and provide measures that are not highly correlated. Results: No significant differences were found between STDRHI2 and STDRLO2 mice in delay discounting. In the Go/No-go task, STDRHI2 mice made more responses during the pre-cue period without committing more false alarms, compared with STDRLO2 mice. Conclusions: The results suggest that short-term selective breeding for high relative alcohol consumption may also select for animals that have impaired response inhibition.

Original languageEnglish (US)
Pages (from-to)1839-1845
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume31
Issue number11
DOIs
StatePublished - Nov 2007

Fingerprint

Impulsive Behavior
Alcohol Drinking
Sucrose
Alcohols
Prednisolone
Reward
Animals
Ethanol
Cues
Pharmaceutical Preparations
Aptitude
Experiments
Alcoholics
Nose
Genetics

Keywords

  • Delay Discounting
  • Go/No-Go Task
  • Impulsivity
  • Inhibition
  • Selected Mouse Lines

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Mouse lines selected for alcohol consumption differ on certain measures of impulsivity. / Wilhelm, Clare; Reeves, Jamie M.; Phillips, Tamara; Mitchell, Suzanne.

In: Alcoholism: Clinical and Experimental Research, Vol. 31, No. 11, 11.2007, p. 1839-1845.

Research output: Contribution to journalArticle

@article{6ba43fbacc8541d2a95f174d7785d26d,
title = "Mouse lines selected for alcohol consumption differ on certain measures of impulsivity",
abstract = "Background: Alcoholics and heavy drinkers score higher on measures of impulsivity than nonalcoholics and light drinkers. This may be due to factors that predate drug exposure (e.g. genetics) or to neuroadaptations associated with exposure to alcohol. The aim of this study was to examine the role of genetics by comparing impulsivity in short-term selected lines of mice bred to voluntarily drink either high (STDRHI2) or low (STDRLO2) amounts of 10{\%} ethanol. Methods: Independent sets of mice completed 2 experiments designed to measure impulsivity. Using the adjusting amount procedure, we examined preference for smaller, sooner rewards over larger but delayed rewards (delay discounting). This task determines the amount of immediate sucrose equivalent to the discounted value of a 20 μl sucrose reward given following a specific delay (0, 2, 4, 8, or 12 seconds). Using a Go/No-go task, we examined the ability of mice to inhibit nose-poking in response to specific cues. These tasks are commonly used to assess different aspects of impulsive behavior, and provide measures that are not highly correlated. Results: No significant differences were found between STDRHI2 and STDRLO2 mice in delay discounting. In the Go/No-go task, STDRHI2 mice made more responses during the pre-cue period without committing more false alarms, compared with STDRLO2 mice. Conclusions: The results suggest that short-term selective breeding for high relative alcohol consumption may also select for animals that have impaired response inhibition.",
keywords = "Delay Discounting, Go/No-Go Task, Impulsivity, Inhibition, Selected Mouse Lines",
author = "Clare Wilhelm and Reeves, {Jamie M.} and Tamara Phillips and Suzanne Mitchell",
year = "2007",
month = "11",
doi = "10.1111/j.1530-0277.2007.00508.x",
language = "English (US)",
volume = "31",
pages = "1839--1845",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Mouse lines selected for alcohol consumption differ on certain measures of impulsivity

AU - Wilhelm, Clare

AU - Reeves, Jamie M.

AU - Phillips, Tamara

AU - Mitchell, Suzanne

PY - 2007/11

Y1 - 2007/11

N2 - Background: Alcoholics and heavy drinkers score higher on measures of impulsivity than nonalcoholics and light drinkers. This may be due to factors that predate drug exposure (e.g. genetics) or to neuroadaptations associated with exposure to alcohol. The aim of this study was to examine the role of genetics by comparing impulsivity in short-term selected lines of mice bred to voluntarily drink either high (STDRHI2) or low (STDRLO2) amounts of 10% ethanol. Methods: Independent sets of mice completed 2 experiments designed to measure impulsivity. Using the adjusting amount procedure, we examined preference for smaller, sooner rewards over larger but delayed rewards (delay discounting). This task determines the amount of immediate sucrose equivalent to the discounted value of a 20 μl sucrose reward given following a specific delay (0, 2, 4, 8, or 12 seconds). Using a Go/No-go task, we examined the ability of mice to inhibit nose-poking in response to specific cues. These tasks are commonly used to assess different aspects of impulsive behavior, and provide measures that are not highly correlated. Results: No significant differences were found between STDRHI2 and STDRLO2 mice in delay discounting. In the Go/No-go task, STDRHI2 mice made more responses during the pre-cue period without committing more false alarms, compared with STDRLO2 mice. Conclusions: The results suggest that short-term selective breeding for high relative alcohol consumption may also select for animals that have impaired response inhibition.

AB - Background: Alcoholics and heavy drinkers score higher on measures of impulsivity than nonalcoholics and light drinkers. This may be due to factors that predate drug exposure (e.g. genetics) or to neuroadaptations associated with exposure to alcohol. The aim of this study was to examine the role of genetics by comparing impulsivity in short-term selected lines of mice bred to voluntarily drink either high (STDRHI2) or low (STDRLO2) amounts of 10% ethanol. Methods: Independent sets of mice completed 2 experiments designed to measure impulsivity. Using the adjusting amount procedure, we examined preference for smaller, sooner rewards over larger but delayed rewards (delay discounting). This task determines the amount of immediate sucrose equivalent to the discounted value of a 20 μl sucrose reward given following a specific delay (0, 2, 4, 8, or 12 seconds). Using a Go/No-go task, we examined the ability of mice to inhibit nose-poking in response to specific cues. These tasks are commonly used to assess different aspects of impulsive behavior, and provide measures that are not highly correlated. Results: No significant differences were found between STDRHI2 and STDRLO2 mice in delay discounting. In the Go/No-go task, STDRHI2 mice made more responses during the pre-cue period without committing more false alarms, compared with STDRLO2 mice. Conclusions: The results suggest that short-term selective breeding for high relative alcohol consumption may also select for animals that have impaired response inhibition.

KW - Delay Discounting

KW - Go/No-Go Task

KW - Impulsivity

KW - Inhibition

KW - Selected Mouse Lines

UR - http://www.scopus.com/inward/record.url?scp=35349016348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35349016348&partnerID=8YFLogxK

U2 - 10.1111/j.1530-0277.2007.00508.x

DO - 10.1111/j.1530-0277.2007.00508.x

M3 - Article

C2 - 17850219

AN - SCOPUS:35349016348

VL - 31

SP - 1839

EP - 1845

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 11

ER -