Mother's lifetime nutrition and the size, shape and efficiency of the placenta

N. R. Winder, G. V. Krishnaveni, S. R. Veena, J. C. Hill, C. L S Karat, Kent Thornburg, C. H D Fall, D. J P Barker

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    Background: Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother's body size. Methods: We studied 522 neonates who were born in a maternity hospital in Mysore, South India. The weight of the placenta and the length and breadth of its surface, were measured after delivery. Results: Higher maternal fat mass predicted a larger placental surface (p = 0.02), while larger maternal head circumference predicted a more oval placental surface (p = 0.03). Higher maternal fat mass and larger maternal head circumference were associated with greater placental efficiency, indicated by lower ratios of the length (p = 0.0003 and p = 0.0001 respectively) and breadth (p = 0.0002 and p <0.0001) of the surface to birthweight. In a sub-sample of 51 mothers whose own birthweight was available, higher maternal birthweight was related to lower ratios of the length and breadth of the surface to birthweight (p = 0.01 and 0.002). Maternal height was unrelated to placental size or shape. Conclusions: Higher maternal fat mass, reflecting the mother's current nutritional state, and larger maternal head circumference, reflecting the mother's fetal/infant growth, are associated with changes in the shape and size of the placental surface and greater placental efficiency. We suggest that these associations reflect effects of the mother's nutrition at different stages of her lifecourse on the development of the placenta and on materno-placento-fetal transfer of nutrients.

    Original languageEnglish (US)
    Pages (from-to)806-810
    Number of pages5
    JournalPlacenta
    Volume32
    Issue number11
    DOIs
    StatePublished - Nov 2011

    Fingerprint

    Placenta
    Mothers
    Fats
    Head
    Maternity Hospitals
    Body Size
    Fetal Development
    India
    Parturition
    Newborn Infant
    Blood Pressure
    Weights and Measures
    Food

    Keywords

    • Birthweight
    • Maternal body composition
    • Placenta
    • Placental efficiency

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Reproductive Medicine
    • Developmental Biology

    Cite this

    Winder, N. R., Krishnaveni, G. V., Veena, S. R., Hill, J. C., Karat, C. L. S., Thornburg, K., ... Barker, D. J. P. (2011). Mother's lifetime nutrition and the size, shape and efficiency of the placenta. Placenta, 32(11), 806-810. https://doi.org/10.1016/j.placenta.2011.09.001

    Mother's lifetime nutrition and the size, shape and efficiency of the placenta. / Winder, N. R.; Krishnaveni, G. V.; Veena, S. R.; Hill, J. C.; Karat, C. L S; Thornburg, Kent; Fall, C. H D; Barker, D. J P.

    In: Placenta, Vol. 32, No. 11, 11.2011, p. 806-810.

    Research output: Contribution to journalArticle

    Winder, NR, Krishnaveni, GV, Veena, SR, Hill, JC, Karat, CLS, Thornburg, K, Fall, CHD & Barker, DJP 2011, 'Mother's lifetime nutrition and the size, shape and efficiency of the placenta', Placenta, vol. 32, no. 11, pp. 806-810. https://doi.org/10.1016/j.placenta.2011.09.001
    Winder, N. R. ; Krishnaveni, G. V. ; Veena, S. R. ; Hill, J. C. ; Karat, C. L S ; Thornburg, Kent ; Fall, C. H D ; Barker, D. J P. / Mother's lifetime nutrition and the size, shape and efficiency of the placenta. In: Placenta. 2011 ; Vol. 32, No. 11. pp. 806-810.
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