Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates

A randomized trial

Joseph Randall Moorman, Waldemar A. Carlo, John Kattwinkel, Robert Schelonka, Peter J. Porcelli, Christina T. Navarrete, Eduardo Bancalari, Judy L. Aschner, Marshall Whit Walker, Jose A. Perez, Charles Palmer, George J. Stukenborg, Douglas E. Lake, Thomas Michael O'Shea

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Objective: To test the hypothesis that heart rate characteristics (HRC) monitoring improves neonatal outcomes. Study design: We conducted a two-group, parallel, individually randomized controlled clinical trial of 3003 very low birth weight infants in 9 neonatal intensive care units. In one group, HRC monitoring was displayed; in the other, it was masked. The primary outcome was number of days alive and ventilator-free in the 120 days after randomization. Secondary outcomes were mortality, number of ventilator days, neonatal intensive care unit stay, and antibiotic use. Results: The mortality rate was reduced in infants whose HRC monitoring was displayed, from 10.2% to 8.1% (hazard ratio, 0.78; 95% CI, 0.61-0.99; P =.04; number needed to monitor = 48), and there was a trend toward increased days alive and ventilator-free (95.9 of 120 days compared with 93.6 in control subjects, P =.08). The mortality benefit was concentrated in infants with a birth weight

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume159
Issue number6
DOIs
StatePublished - Dec 2011
Externally publishedYes

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Very Low Birth Weight Infant
Mechanical Ventilators
Heart Rate
Neonatal Intensive Care Units
Newborn Infant
Mortality
Random Allocation
Birth Weight
Randomized Controlled Trials
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates : A randomized trial. / Moorman, Joseph Randall; Carlo, Waldemar A.; Kattwinkel, John; Schelonka, Robert; Porcelli, Peter J.; Navarrete, Christina T.; Bancalari, Eduardo; Aschner, Judy L.; Whit Walker, Marshall; Perez, Jose A.; Palmer, Charles; Stukenborg, George J.; Lake, Douglas E.; Michael O'Shea, Thomas.

In: Journal of Pediatrics, Vol. 159, No. 6, 12.2011.

Research output: Contribution to journalArticle

Moorman, JR, Carlo, WA, Kattwinkel, J, Schelonka, R, Porcelli, PJ, Navarrete, CT, Bancalari, E, Aschner, JL, Whit Walker, M, Perez, JA, Palmer, C, Stukenborg, GJ, Lake, DE & Michael O'Shea, T 2011, 'Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: A randomized trial', Journal of Pediatrics, vol. 159, no. 6. https://doi.org/10.1016/j.jpeds.2011.06.044
Moorman, Joseph Randall ; Carlo, Waldemar A. ; Kattwinkel, John ; Schelonka, Robert ; Porcelli, Peter J. ; Navarrete, Christina T. ; Bancalari, Eduardo ; Aschner, Judy L. ; Whit Walker, Marshall ; Perez, Jose A. ; Palmer, Charles ; Stukenborg, George J. ; Lake, Douglas E. ; Michael O'Shea, Thomas. / Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates : A randomized trial. In: Journal of Pediatrics. 2011 ; Vol. 159, No. 6.
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