Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury

Shide Badri, Jasper Chen, Jason Barber, Nancy R. Temkin, Sureyya S. Dikmen, Randall M. Chesnut, Steven Deem, Norbert Yanez, Miriam Treggiari

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Purpose: Elevated intracranial pressure (ICP) has been associated with increased mortality in patients with severe traumatic brain injury (TBI). We have examined whether raised ICP is independently associated with mortality, functional status and neuropsychological functioning in adult TBI patients. Methods: Data from a randomized trial of 499 participants were secondarily analyzed. The primary endpoints were mortality and a composite measure of functional status and neuropsychological function (memory, speed of information processing, executive function) over a 6-month period. The area under the curve of the ICP profile (average ICP) during the first 48 h of monitoring was the main predictor of interest. Multivariable regression was used to adjust for a priori defined confounders: age, Glasgow Coma Score, Abbreviated Injury Scale-head and hypoxia. Results: Of the participants, 365 patients had complete 48-h ICP data. The overall 6-month mortality was 18 %. The adjusted odds ratio of mortality comparing 10-mmHg increases in average ICP was 3.12 (95 % confidence interval 1.79, 5.44; p

Original languageEnglish (US)
Pages (from-to)1800-1809
Number of pages10
JournalIntensive Care Medicine
Volume38
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Intracranial Pressure
Mortality
Abbreviated Injury Scale
Intracranial Hypertension
Executive Function
Coma
Automatic Data Processing
Area Under Curve
Odds Ratio
Head
Traumatic Brain Injury
Confidence Intervals

Keywords

  • Critical care
  • Functional outcome
  • Intracranial hypertension
  • Intracranial pressure
  • Neuropsychological tests
  • Traumatic brain injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. / Badri, Shide; Chen, Jasper; Barber, Jason; Temkin, Nancy R.; Dikmen, Sureyya S.; Chesnut, Randall M.; Deem, Steven; Yanez, Norbert; Treggiari, Miriam.

In: Intensive Care Medicine, Vol. 38, No. 11, 11.2012, p. 1800-1809.

Research output: Contribution to journalArticle

Badri, Shide ; Chen, Jasper ; Barber, Jason ; Temkin, Nancy R. ; Dikmen, Sureyya S. ; Chesnut, Randall M. ; Deem, Steven ; Yanez, Norbert ; Treggiari, Miriam. / Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. In: Intensive Care Medicine. 2012 ; Vol. 38, No. 11. pp. 1800-1809.
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