Morphometric analysis of human retinal pigment epithelium: Correlation with age and location

Robert C. Watzke, Jaymee Delaney Soldevilla, Dennis Trune

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Flat bleached preparations of retinal pigment epithelial (RPE) cells from foveal, temporal posterior pole, and temporal equatorial fundus locations of 20 normal human eyes from donors age ranked from 13 to 96 years were analyzed for density, and 10 were analyzed for area, hexagonality and polymegathism. These factors were related to fundus locations and age. Foveal RPE cells were significantly more dense and more hexagonal in eyes from younger donors. Loss of hexagonality in the fovea, but not elsewhere, was correlated with increasing age. As the eye ages, foveal RPE cells selectively lose unique morphologic characteristics and resemble nonfoveal cells. These morphologic changes resemble other pathologic features of age-related degeneration in their proclivity for the fovea and posterior pole.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalCurrent Eye Research
Volume12
Issue number2
DOIs
StatePublished - 1993

Fingerprint

Retinal Pigments
Retinal Pigment Epithelium
Epithelial Cells

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Morphometric analysis of human retinal pigment epithelium : Correlation with age and location. / Watzke, Robert C.; Soldevilla, Jaymee Delaney; Trune, Dennis.

In: Current Eye Research, Vol. 12, No. 2, 1993, p. 133-142.

Research output: Contribution to journalArticle

Watzke, Robert C. ; Soldevilla, Jaymee Delaney ; Trune, Dennis. / Morphometric analysis of human retinal pigment epithelium : Correlation with age and location. In: Current Eye Research. 1993 ; Vol. 12, No. 2. pp. 133-142.
@article{1bc4269f4b864494a6f7ba2c85a7ac95,
title = "Morphometric analysis of human retinal pigment epithelium: Correlation with age and location",
abstract = "Flat bleached preparations of retinal pigment epithelial (RPE) cells from foveal, temporal posterior pole, and temporal equatorial fundus locations of 20 normal human eyes from donors age ranked from 13 to 96 years were analyzed for density, and 10 were analyzed for area, hexagonality and polymegathism. These factors were related to fundus locations and age. Foveal RPE cells were significantly more dense and more hexagonal in eyes from younger donors. Loss of hexagonality in the fovea, but not elsewhere, was correlated with increasing age. As the eye ages, foveal RPE cells selectively lose unique morphologic characteristics and resemble nonfoveal cells. These morphologic changes resemble other pathologic features of age-related degeneration in their proclivity for the fovea and posterior pole.",
author = "Watzke, {Robert C.} and Soldevilla, {Jaymee Delaney} and Dennis Trune",
year = "1993",
doi = "10.3109/02713689308999481",
language = "English (US)",
volume = "12",
pages = "133--142",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Morphometric analysis of human retinal pigment epithelium

T2 - Correlation with age and location

AU - Watzke, Robert C.

AU - Soldevilla, Jaymee Delaney

AU - Trune, Dennis

PY - 1993

Y1 - 1993

N2 - Flat bleached preparations of retinal pigment epithelial (RPE) cells from foveal, temporal posterior pole, and temporal equatorial fundus locations of 20 normal human eyes from donors age ranked from 13 to 96 years were analyzed for density, and 10 were analyzed for area, hexagonality and polymegathism. These factors were related to fundus locations and age. Foveal RPE cells were significantly more dense and more hexagonal in eyes from younger donors. Loss of hexagonality in the fovea, but not elsewhere, was correlated with increasing age. As the eye ages, foveal RPE cells selectively lose unique morphologic characteristics and resemble nonfoveal cells. These morphologic changes resemble other pathologic features of age-related degeneration in their proclivity for the fovea and posterior pole.

AB - Flat bleached preparations of retinal pigment epithelial (RPE) cells from foveal, temporal posterior pole, and temporal equatorial fundus locations of 20 normal human eyes from donors age ranked from 13 to 96 years were analyzed for density, and 10 were analyzed for area, hexagonality and polymegathism. These factors were related to fundus locations and age. Foveal RPE cells were significantly more dense and more hexagonal in eyes from younger donors. Loss of hexagonality in the fovea, but not elsewhere, was correlated with increasing age. As the eye ages, foveal RPE cells selectively lose unique morphologic characteristics and resemble nonfoveal cells. These morphologic changes resemble other pathologic features of age-related degeneration in their proclivity for the fovea and posterior pole.

UR - http://www.scopus.com/inward/record.url?scp=0027534638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027534638&partnerID=8YFLogxK

U2 - 10.3109/02713689308999481

DO - 10.3109/02713689308999481

M3 - Article

C2 - 8449024

AN - SCOPUS:0027534638

VL - 12

SP - 133

EP - 142

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 2

ER -