Morphology of developing motoneurons innervating the medial gastrocnemius of the cat

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The morphology of medial gastrocnemius (MG) motoneurons labeled by retrograde transport of horseradish peroxidase was quantified in 5 postnatal ages (3 to 79-86 days) and in adults. A bimodal distribution of somal volumes was evident at birth which permitted separating the motoneurons into alpha and gamma subpopulations for analysis. There was a significant increase in the axial dimensions, surface area and volume calculated for both alpha and gamma cell bodies between each of the age-groups studied. A greater relative growth of the major over minor axis for the gammas produced a significant decrease in the form factor (i.e. greater eccentricity) between the youngest and oldest age-groups. The number of primary dendrites observed remained constant throughout postnatal development. The surface area of alpha somata more than tripled while that of the gammas doubled from 3 days to the adult. The mean somal volume of an alpha motoneuron at birth was only 17% of its adult value while the gamma cell bodies were 33% of their adult volume. A positive correlation was found for both alpha and gamma motoneurons when their somal surface area was plotted against postnatal age and weight. The rate of growth of the MG somal surface area is compared to the changes found in axonal conduction velocity and axonal diameter for MG in the literature.

Original languageEnglish (US)
Pages (from-to)253-263
Number of pages11
JournalDevelopmental Brain Research
Volume49
Issue number2
DOIs
StatePublished - Oct 1 1989
Externally publishedYes

Fingerprint

Motor Neurons
Cats
Age Groups
Parturition
Carisoprodol
Horseradish Peroxidase
Growth
Dendrites
Weights and Measures
Cell Body

Keywords

  • Cell body
  • Development
  • Feline
  • Morphology
  • Motoneuron
  • Neuroanatomy
  • Spinal cord

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Morphology of developing motoneurons innervating the medial gastrocnemius of the cat. / Cameron, William; Fang, He.

In: Developmental Brain Research, Vol. 49, No. 2, 01.10.1989, p. 253-263.

Research output: Contribution to journalArticle

@article{4dc438628b6c43469c96384c5dcf94df,
title = "Morphology of developing motoneurons innervating the medial gastrocnemius of the cat",
abstract = "The morphology of medial gastrocnemius (MG) motoneurons labeled by retrograde transport of horseradish peroxidase was quantified in 5 postnatal ages (3 to 79-86 days) and in adults. A bimodal distribution of somal volumes was evident at birth which permitted separating the motoneurons into alpha and gamma subpopulations for analysis. There was a significant increase in the axial dimensions, surface area and volume calculated for both alpha and gamma cell bodies between each of the age-groups studied. A greater relative growth of the major over minor axis for the gammas produced a significant decrease in the form factor (i.e. greater eccentricity) between the youngest and oldest age-groups. The number of primary dendrites observed remained constant throughout postnatal development. The surface area of alpha somata more than tripled while that of the gammas doubled from 3 days to the adult. The mean somal volume of an alpha motoneuron at birth was only 17{\%} of its adult value while the gamma cell bodies were 33{\%} of their adult volume. A positive correlation was found for both alpha and gamma motoneurons when their somal surface area was plotted against postnatal age and weight. The rate of growth of the MG somal surface area is compared to the changes found in axonal conduction velocity and axonal diameter for MG in the literature.",
keywords = "Cell body, Development, Feline, Morphology, Motoneuron, Neuroanatomy, Spinal cord",
author = "William Cameron and He Fang",
year = "1989",
month = "10",
day = "1",
doi = "10.1016/0165-3806(89)90026-6",
language = "English (US)",
volume = "49",
pages = "253--263",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Morphology of developing motoneurons innervating the medial gastrocnemius of the cat

AU - Cameron, William

AU - Fang, He

PY - 1989/10/1

Y1 - 1989/10/1

N2 - The morphology of medial gastrocnemius (MG) motoneurons labeled by retrograde transport of horseradish peroxidase was quantified in 5 postnatal ages (3 to 79-86 days) and in adults. A bimodal distribution of somal volumes was evident at birth which permitted separating the motoneurons into alpha and gamma subpopulations for analysis. There was a significant increase in the axial dimensions, surface area and volume calculated for both alpha and gamma cell bodies between each of the age-groups studied. A greater relative growth of the major over minor axis for the gammas produced a significant decrease in the form factor (i.e. greater eccentricity) between the youngest and oldest age-groups. The number of primary dendrites observed remained constant throughout postnatal development. The surface area of alpha somata more than tripled while that of the gammas doubled from 3 days to the adult. The mean somal volume of an alpha motoneuron at birth was only 17% of its adult value while the gamma cell bodies were 33% of their adult volume. A positive correlation was found for both alpha and gamma motoneurons when their somal surface area was plotted against postnatal age and weight. The rate of growth of the MG somal surface area is compared to the changes found in axonal conduction velocity and axonal diameter for MG in the literature.

AB - The morphology of medial gastrocnemius (MG) motoneurons labeled by retrograde transport of horseradish peroxidase was quantified in 5 postnatal ages (3 to 79-86 days) and in adults. A bimodal distribution of somal volumes was evident at birth which permitted separating the motoneurons into alpha and gamma subpopulations for analysis. There was a significant increase in the axial dimensions, surface area and volume calculated for both alpha and gamma cell bodies between each of the age-groups studied. A greater relative growth of the major over minor axis for the gammas produced a significant decrease in the form factor (i.e. greater eccentricity) between the youngest and oldest age-groups. The number of primary dendrites observed remained constant throughout postnatal development. The surface area of alpha somata more than tripled while that of the gammas doubled from 3 days to the adult. The mean somal volume of an alpha motoneuron at birth was only 17% of its adult value while the gamma cell bodies were 33% of their adult volume. A positive correlation was found for both alpha and gamma motoneurons when their somal surface area was plotted against postnatal age and weight. The rate of growth of the MG somal surface area is compared to the changes found in axonal conduction velocity and axonal diameter for MG in the literature.

KW - Cell body

KW - Development

KW - Feline

KW - Morphology

KW - Motoneuron

KW - Neuroanatomy

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0024447219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024447219&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(89)90026-6

DO - 10.1016/0165-3806(89)90026-6

M3 - Article

C2 - 2805334

AN - SCOPUS:0024447219

VL - 49

SP - 253

EP - 263

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 2

ER -