Morphological changes of astrocyte like cells induced by serum β lipoprotein in brain cell culture

H. Offner, G. Konat, J. Clausen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

When added to brain cell cultures of newborn rats, serum and, in particular, its β lipoprotein fraction caused significant morphological transformations of astrocyte like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of β lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood brain and blood spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum β lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalNEUROBIOLOGY
Volume5
Issue number3
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Neuroscience(all)

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