Morphological changes of astrocyte like cells induced by serum β lipoprotein in brain cell culture

Halina Offner, G. Konat, J. Clausen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

When added to brain cell cultures of newborn rats, serum and, in particular, its β lipoprotein fraction caused significant morphological transformations of astrocyte like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of β lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood brain and blood spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum β lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalNeurobiology
Volume5
Issue number3
StatePublished - 1975
Externally publishedYes

Fingerprint

Astrocytes
Lipoproteins
Cell Culture Techniques
Brain
Serum
Multiple Sclerosis
Blood Proteins
Central Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Morphological changes of astrocyte like cells induced by serum β lipoprotein in brain cell culture. / Offner, Halina; Konat, G.; Clausen, J.

In: Neurobiology, Vol. 5, No. 3, 1975, p. 192-196.

Research output: Contribution to journalArticle

@article{b9a375f572e1450491f602e01e2c3ee1,
title = "Morphological changes of astrocyte like cells induced by serum β lipoprotein in brain cell culture",
abstract = "When added to brain cell cultures of newborn rats, serum and, in particular, its β lipoprotein fraction caused significant morphological transformations of astrocyte like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of β lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood brain and blood spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum β lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.",
author = "Halina Offner and G. Konat and J. Clausen",
year = "1975",
language = "English (US)",
volume = "5",
pages = "192--196",
journal = "Ideggyogyaszati Szemle",
issn = "0019-1442",
publisher = "Ifjusagi Lap-es Konyvkiado Vallalat",
number = "3",

}

TY - JOUR

T1 - Morphological changes of astrocyte like cells induced by serum β lipoprotein in brain cell culture

AU - Offner, Halina

AU - Konat, G.

AU - Clausen, J.

PY - 1975

Y1 - 1975

N2 - When added to brain cell cultures of newborn rats, serum and, in particular, its β lipoprotein fraction caused significant morphological transformations of astrocyte like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of β lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood brain and blood spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum β lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.

AB - When added to brain cell cultures of newborn rats, serum and, in particular, its β lipoprotein fraction caused significant morphological transformations of astrocyte like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of β lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood brain and blood spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum β lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.

UR - http://www.scopus.com/inward/record.url?scp=0016794495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016794495&partnerID=8YFLogxK

M3 - Article

C2 - 170552

AN - SCOPUS:0016794495

VL - 5

SP - 192

EP - 196

JO - Ideggyogyaszati Szemle

JF - Ideggyogyaszati Szemle

SN - 0019-1442

IS - 3

ER -