When added to brain cell cultures of newborn rats, serum and, in particular, its β lipoprotein fraction caused significant morphological transformations of astrocyte like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of β lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood brain and blood spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum β lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Dec 1 1975|
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