Abstract
When added to brain cell cultures of newborn rats, serum and, in particular, its β lipoprotein fraction caused significant morphological transformations of astrocyte like cells present in the culture. The changes were instantaneous as they appeared within 1 min after addition of β lipoprotein and they were characterized by swelling and loss of cellular processes of all astrocyte like cells present. The lipoprotein effect was reversed after a period of about 7 h. Since the blood brain and blood spinal fluid barrier in multiple sclerosis is decreased towards serum macromolecules, i.e. the serum β lipoprotein, this protein may enter the central nervous system and thereby initiate a demyelinating process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 192-196 |
| Number of pages | 5 |
| Journal | NEUROBIOLOGY |
| Volume | 5 |
| Issue number | 3 |
| State | Published - 1975 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Neuroscience