TY - JOUR
T1 - Morphologic and molecular changes in the placenta
T2 - what we can learn from environmental exposures
AU - Vrooman, Lisa A.
AU - Xin, Frances
AU - Bartolomei, Marisa S.
N1 - Publisher Copyright:
© 2016 American Society for Reproductive Medicine
PY - 2016/9/15
Y1 - 2016/9/15
N2 - In mammals, the extraembryonic tissues, which include the placenta, are crucial for embryonic development and growth. Because the placenta is no longer needed for postnatal life, however, it has been relatively understudied as a tissue of interest in biomedical research. Recently, increased efforts have been placed on understanding the placenta and how it may play a key role in human health and disease. In this review, we discuss two very different types of environmental exposures: assisted reproductive technologies and in utero exposure to endocrine-disrupting chemicals. We summarize the current literature on their effects on placental development in both rodent and human, and comment on the potential use of placental biomarkers as predictors of offspring health outcomes.
AB - In mammals, the extraembryonic tissues, which include the placenta, are crucial for embryonic development and growth. Because the placenta is no longer needed for postnatal life, however, it has been relatively understudied as a tissue of interest in biomedical research. Recently, increased efforts have been placed on understanding the placenta and how it may play a key role in human health and disease. In this review, we discuss two very different types of environmental exposures: assisted reproductive technologies and in utero exposure to endocrine-disrupting chemicals. We summarize the current literature on their effects on placental development in both rodent and human, and comment on the potential use of placental biomarkers as predictors of offspring health outcomes.
KW - Placenta
KW - assisted reproductive technologies
KW - endocrine disrupting chemicals
KW - epigenetics
UR - http://www.scopus.com/inward/record.url?scp=84989881993&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989881993&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2016.08.016
DO - 10.1016/j.fertnstert.2016.08.016
M3 - Review article
C2 - 27523298
AN - SCOPUS:84989881993
SN - 0015-0282
VL - 106
SP - 930
EP - 940
JO - Fertility and sterility
JF - Fertility and sterility
IS - 4
ER -