Morphologic and molecular changes in the placenta: what we can learn from environmental exposures

Lisa A. Vrooman, Frances Xin, Marisa S. Bartolomei

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


In mammals, the extraembryonic tissues, which include the placenta, are crucial for embryonic development and growth. Because the placenta is no longer needed for postnatal life, however, it has been relatively understudied as a tissue of interest in biomedical research. Recently, increased efforts have been placed on understanding the placenta and how it may play a key role in human health and disease. In this review, we discuss two very different types of environmental exposures: assisted reproductive technologies and in utero exposure to endocrine-disrupting chemicals. We summarize the current literature on their effects on placental development in both rodent and human, and comment on the potential use of placental biomarkers as predictors of offspring health outcomes.

Original languageEnglish (US)
Pages (from-to)930-940
Number of pages11
JournalFertility and sterility
Issue number4
StatePublished - Sep 15 2016
Externally publishedYes


  • Placenta
  • assisted reproductive technologies
  • endocrine disrupting chemicals
  • epigenetics

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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