Morphine enhances adenosine release from the in vivo rat cerebral cortex

J. W. Phillis, Zhi-Gen Jiang, B. J. Chelack, P. H. Wu

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux of purines from intact rat cerebral cortices prelabelled with 3H-adenosine. Naloxone antagonized morphine's action. It is suggested that the depressant actions of morphine on transmission in the central nervous system may be related to this enhancement of extracellular levels of adenosine and the adenine nucleotides.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalEuropean Journal of Pharmacology
Volume65
Issue number1
StatePublished - 1980
Externally publishedYes

Fingerprint

Cerebral Cortex
Adenosine
Morphine
Purines
Adenine Nucleotides
Naloxone
Central Nervous System

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Phillis, J. W., Jiang, Z-G., Chelack, B. J., & Wu, P. H. (1980). Morphine enhances adenosine release from the in vivo rat cerebral cortex. European Journal of Pharmacology, 65(1), 97-100.

Morphine enhances adenosine release from the in vivo rat cerebral cortex. / Phillis, J. W.; Jiang, Zhi-Gen; Chelack, B. J.; Wu, P. H.

In: European Journal of Pharmacology, Vol. 65, No. 1, 1980, p. 97-100.

Research output: Contribution to journalArticle

Phillis, JW, Jiang, Z-G, Chelack, BJ & Wu, PH 1980, 'Morphine enhances adenosine release from the in vivo rat cerebral cortex', European Journal of Pharmacology, vol. 65, no. 1, pp. 97-100.
Phillis, J. W. ; Jiang, Zhi-Gen ; Chelack, B. J. ; Wu, P. H. / Morphine enhances adenosine release from the in vivo rat cerebral cortex. In: European Journal of Pharmacology. 1980 ; Vol. 65, No. 1. pp. 97-100.
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