Morphine and naloxone, IP or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex

Pedro V. Rada, Gregory Mark, Kathleen M. Taylor, Hartley G. Hoebel

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

In rats with microdialysis probes in the nucleus accumbens (NAc) or prefrontal cortex (PFC), intraperitoneally (IP) delivered morphine on the 8th day of escalating doses decreased extracellular ACh in the NAc. On day 9, naloxone (5 mg/kg) precipitated withdrawal and increased the release of ACh. When morphine and methylnaloxonium were given locally into the NAc by reverse dialysis, the opiate again decreased extracellular ACh, and the opiate antagonist increased it. These effects were proportional to the dose of local infusions. Local morphine had the same ACh-lowering effect in morphine-dependent and nondependent rats, whereas local methylnaloxonium increased extracellular ACh significantly more in morphine-dependent animals. Systemic and local effects on ACh systems in the PFC were more complicated and showed some relation to locomotor activity. The results suggest that intrinsic ACh neurons in the NAc have a special relationship to opiate reinforcement such that extracellular ACh is low in response to morphine and high during withdrawal. Thus, low ACh may correlate with opiate reward, and high ACh with aversion.

Original languageEnglish (US)
Pages (from-to)809-816
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume53
Issue number4
DOIs
StatePublished - Apr 1996

Fingerprint

Opiate Alkaloids
Naloxone
Prefrontal Cortex
Morphine
Acetylcholine
Nucleus Accumbens
Rats
Dialysis
Microdialysis
Locomotion
Reward
Neurons
Reinforcement
Animals

Keywords

  • Acetylcholine
  • Addiction
  • Methylnaloxonium
  • Microdialysis
  • Morphine
  • Nucleus accumbens
  • Opiates
  • Prefrontal cortex
  • Rats
  • Withdrawal

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Morphine and naloxone, IP or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex. / Rada, Pedro V.; Mark, Gregory; Taylor, Kathleen M.; Hoebel, Hartley G.

In: Pharmacology Biochemistry and Behavior, Vol. 53, No. 4, 04.1996, p. 809-816.

Research output: Contribution to journalArticle

Rada, Pedro V. ; Mark, Gregory ; Taylor, Kathleen M. ; Hoebel, Hartley G. / Morphine and naloxone, IP or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex. In: Pharmacology Biochemistry and Behavior. 1996 ; Vol. 53, No. 4. pp. 809-816.
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